Results 101 to 110 of about 1,618,312 (332)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

LarvaTracing : Imagerie RMN des infestations dans les œuvres d’art en bois et matériaux organiques

In Situ, 2019
The infestation of a work of art may be destructive for the piece itself and also presents the threat of spreading throughout an entire collection. Several methods are available to museums in order to diagnose an infestation at an early stage and then ...
Grazia Nicosia, Hervé Mathieu, Joëlle Le Roux, Anne de Wallens, Michel Dojat   +4 more
doaj   +1 more source

Urban Containment Policies and Physical Activity A Time–Series Analysis of Metropolitan Areas, 1990–2002 [PDF]

, 2008
Background: Urban containment policies attempt to manage the location, character, and timing of growth to support a variety of goals such as compact development, preservation of greenspace, and efficient use of infrastructure.
Aytur, Semra, Catellier, Diane J, Evenson, Kelly R, Rodriguez, Daniel A   +3 more
core   +2 more sources

Management of hypertension at the community level in Sub-Saharan Africa (SSA): towards a rational use of available resources [PDF]

, 2011
Hypertension is emerging in many developing nations as a leading cause of cardiovascular mortality, morbidity and disability in adults. In sub-Saharan African (SSA) countries it has specificities such as occurring in young and active adults, resulting in
Twagirumukiza, Marc, Van Bortel, Lucas
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Web-GIS approach to preventive conservation of heritage buildings

Automation in Construction, 2020
The effective implementation of preventive conservation approaches demands the employment of standardized and robust tools able to integrate the data coming from multiple sources, inspection and diagnosis techniques, as well as to ensure the proper ...
L. Sánchez-Aparicio, M. Masciotta, J. García-Alvarez, Luís F. Ramos, D. Oliveira, J. Martín-Jiménez, D. González-Aguilera, P. Monteiro   +7 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Digital-based Integrated Methodology for the Preventive Conservation of Cultural Heritage: The Experience of HeritageCare Project

International Journal of Architectural Heritage, 2019
A sustainable conservation strategy for cultural heritage protection is not feasible without a systematic documentation, registration and management of the information. The adoption of integrated inspection protocols and regular tracking processes, based
M. Masciotta, Maria José Cruz Morais, Luís F. Ramos, D. Oliveira, L. Sánchez-Aparicio, D. González-Aguilera   +5 more
semanticscholar   +1 more source

Not all surveillance data are created equal—A multi‐method dynamic occupancy approach to determine rabies elimination from wildlife [PDF]

, 2019
1. A necessary component of elimination programmes for wildlife disease is effective surveillance. The ability to distinguish between disease freedom and non‐detection can mean the difference between a successful elimination campaign and new epizootics ...
Cliquet F., Gelman A., Glueck T. F., Gruen B., Homer C., MacKenzie D. I., Manning S. E., Mörner T., R Core Team, Ronald G., Rupprecht C.   +10 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source