Results 81 to 90 of about 1,886,210 (293)

Determining Appropriate Preservation Conditions for Historical Mixed-Media Objects: a Risk-Based Approach

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2019
Historical mixed-media objects consist of a wide range of materials that can be organic and inorganic in nature. They are often fragile due to the nature of the materials used, and their advanced state of degradation.
Willemien Anaf, Marjolijn Debulpaep
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Methodology for the Monitoring and Control of the Alterations Related to Biodeterioration and Physical-Chemical Processes Produced on the Paintings on the Ceiling of the Polychrome Hall at Altamira

Conservation
On the surface of the Cave of Altamira’s prehistoric paintings, a series of active deterioration processes are evident, leading to significant alterations of this invaluable heritage.
Alfredo Prada, Vicente Bayarri
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Conservação preventiva para instituições cariocas que custodiam bens culturais

Acervo, 2011
O presente trabalho aborda o projeto cooperativo Brasil-Cuba de conservação preventiva desenvolvido no âmbito de instituições cariocas custodiadoras de bens culturais.
Milagros Vaillant Callol
doaj  

Preventive Conservation of a Short Theatre Skit (Valencian "Sainete") with Cloud Data Storage and Internet of Things. [PDF]

Sensors (Basel), 2023
Verdesoto I, Fernández-Navajas Á, Beltrán-Roca PJ, García-Diego FJ.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Análisis fisicoquímico de materiales de embalaje utilizados para almacenar documentos históricos/patrimoniales en instituciones culturales públicas de Costa Rica

Información, Cultura y Sociedad
Para determinar la aptitud de materiales de embalaje elaborados en papel/cartón y empleados en diferentes instituciones públicas a cargo de patrimonio documental costarricense, se llevó a cabo la medición de la acidez (pH) de los materiales, así como el ...
Sharon Ugalde Soto, Camila Hernández Murillo, Karla Abarca Montero   +2 more
doaj   +1 more source