Results 101 to 110 of about 1,886,210 (293)

Preventive Conservation: People, Objects, Place and Time in the Philippines

, 2018
Preventive conservation, with its origins grounded in the material fabric of cultural material, is in a period of transformation, with numerous practitioners, in and outside of the field of conservation, considering its broader and holistic objectives ...
Scott, M, Labrador, AMT, Tse, N, Balarbar, R   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

The importance of preventive conservation in the history of the conservation and restoration of cultural property

, 2018
Se muestra un proyecto puesto en marcha en el marco docente de la asignatura Teoría e Historia de la Conservación y Restauración de Bienes Culturales del Grado de Conservación y Restauración de la Facultad de Bellas Artes de la Universidad de Sevilla ...
Ruiz-de-Lacanal, María-Dolores, Medina Castell, Eva M., Hernández Romero, Carlos Manuel, International Institute for Conservation of Historic and Artistic Works (Coordinador), Serrano Larrea, Carmen   +4 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Preventive Conservation of Monuments and Sites [PDF]

, 2009
Invited introduction to the theme of the publication, from the UNESCO chair on preventive conservation, monitoring and maintenance of monuments and sites perspectivesponsorship: PRECOMOS Unesco chair at K.U.Leuvenstatus ...
Van Balen, Koenraad
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Bio-Inspired 3D-Printed Modular System for Protection of Historic Floors: From Multilevel Knowledge to a Customized Solution

Heritage
Historic floors, including mosaics, stone slabs, and decorated pavements, are fragile elements that can be easily damaged during restoration works. Risks arise from falling tools, concentrated loads of scaffolding or equipment, and the repeated passage ...
Ernesto Grande, Maura Imbimbo, Assunta Pelliccio, Valentina Tomei   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reporting on the Fountains and Monuments in Turin Project: A Proposal for the Preventive and Planned Conservation of Outdoor Cultural Heritage

Heritage
The conservation of cultural heritage increasingly requires a transition from emergency restoration to preventive and planned strategies supported by systematic data management. Within this context, this paper, conceived as a project report, presents the
Francesca Bocasso, Michela Cardinali, Laura Fornara, Paola Manchinu, Virginia Valesio   +4 more
doaj   +1 more source