Results 111 to 120 of about 125,549 (303)
F as in Fat: How Obesity Policies Are Failing in America, 2005 [PDF]
, 2005 Examines national and state obesity rates and government policies. Challenges the research community to focus on major research questions to inform policy decisions, and policymakers to pursue actions to combat the obesity ...
Chrissie Juliano +4 more
core
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Archives Conservation Discussion Group 2011: Digitization and Its Effect on Conservation Treatment Decisions: How Has Wide-Spread Digitizing of Collections Changed Our Approach to Treatment? [PDF]
, 2011 In line with this year’s AIC theme: ETHOS, LOGOS, PATHOS: ethical principles and critical thinking in conservation, The Archives Conservation Discussion Group 2011 examined the impact of providing digital collections in museums and libraries, and their ...
Miller, Laura, Tedone, Melissa
core +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Barnes Hospital Bulletin [PDF]
, 1977 https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1136/thumbnail ...
core +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
HeritageHistoric floors, including mosaics, stone slabs, and decorated pavements, are fragile elements that can be easily damaged during restoration works. Risks arise from falling tools, concentrated loads of scaffolding or equipment, and the repeated passage ...
Ernesto Grande +3 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
HeritageThe conservation of cultural heritage increasingly requires a transition from emergency restoration to preventive and planned strategies supported by systematic data management. Within this context, this paper, conceived as a project report, presents the
Francesca Bocasso +4 more
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source