Results 111 to 120 of about 123,273 (258)

OPTIMIZATION RESEARCH OF PREVENTIVE MAINTENANCE STRATEGY ON THE CATENARY SYSTEM BASED ON RELIABILITY CONSTRAINTS

Jixie qiangdu, 2016
Optimization research on reliability of the catenary system and preventive maintenance strategy is the key to ensure the safe operation of the electrical railway.
LIU Huan, LIU ZhiGang, JIANG Jing
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Silicone Resin Polymer Used in Preventive Maintenance of Asphalt Mixture Based on Fog Seal. [PDF]

Polymers (Basel), 2019
Cui P, Wu S, Xu H, Lv Y.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Machine learning approaches for predicting preventive maintenance costs of expressways in Xinjiang. [PDF]

PLoS One
Jia C, An J, Ma S, Dai X.
europepmc   +1 more source

Development of a monitoring scheme for preventive maintenance of the cement machinery. [PDF]

Springerplus, 2016
Alhajjaji M, Boubeker B, Eljoumani S, Zamma A, Idiri M, Atik H.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on optimization of C4 repair operation of Harmony electric locomotive based on preventive maintenance. [PDF]

PLoS One
Liu Y, Wu J, Wu Q.
europepmc   +1 more source

Optimizing preventive maintenance policy: A data-driven application for a light rail braking system. [PDF]

Proc Inst Mech Eng O J Risk Reliab, 2017
Corman F, Kraijema S, Godjevac M, Lodewijks G.   +3 more
europepmc   +1 more source