Results 101 to 110 of about 1,612,807 (286)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Maintenance program for Electric Vehicles power train by Reliability Centred Maintenance [PDF]

open access: yes, 2012
The reduction of environmental pollution is one of the greatest challenges for humanity, today and for the immediate future. Air quality is one of the most critical aspects in determining people’s health, particularly in big cities, and transportation ...
MACCIONI, FEDERICO
core  

Optimal railway infrastructure maintenance and repair policies to manage risk under uncertainty with adaptive control [PDF]

open access: yes, 2006
The aim of this paper is to apply two adaptive control formulations under uncertainty, say open-loop and closed-loop, to the process of developing maintenance and repair policies for railway infrastructures.
Pérez, Jose M.   +3 more
core   +1 more source

Determination of a model of preventive maintenance of special purpose vehicles

open access: yesVojnotehnički Glasnik
Introduction/purpose: The aim of this paper is to obtain quantitative and qualitative indicators of vehicle condition and reliability based on operational data which can be used to determine the optimal periodicity of preventive maintenance for special ...
Stojko Lj. Biočanin   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Modeling and solving the periodic maintenance problem. [PDF]

open access: yes
We study the problem of scheduling maintenance services. Given is a set of m machines and integral cost-coefficients a(i) and b(i) for each machine i (1Branch-and-price; Column generation; Costs; Linear programming; Model; Models; Optimal; Scheduling ...
Grigoriev, A   +2 more
core  

ON A PREVENTIVE MAINTENANCE WITH MONITORED SYSTEM

open access: yesJournal of the Operations Research Society of Japan, 1979
A monitored system consists of a core system and its monitor. A core system follows a general life time distribution, but its state, good or not good, cannot be observed directly. In order to infer the state of the core system, we use the information from the monitor whose states are stochasticalIy related to the states of the core system.
openaire   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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