Results 91 to 100 of about 431,604 (298)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Jointly Production and Correlated Maintenance Optimization for Parallel Leased Machines
Applied Sciences, 2017 This paper deals with a preventive maintenance strategy optimization correlated to production for a manufacturing system made by several parallel machines under lease contract. In order to minimize the total cost of production and maintenance by reducing
Tarek ASKRI, Zied HAJEJ, Nidhal REZG
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Integrated Production-Distribution Planning with Considering Preventive Maintenance [PDF]
, 2007 The preventive maintenance activity is important thing in production system especially for a continuous production process, for example in fertilizer industry. Therefore, it has to be considered in production-distribution planning. This paper considers
Nur Bahagia, Senator +3 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The technical systems preventive maintenance trade-off model
Vojnotehnički Glasnik, 1996 A complex technical system preventive maintenance model based on a 'trade-off' between maximum availability and cost-effectiveness criterions was developed.
Svetomir Minić +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The modern approach to preventive maintenance of parasitic diseases
Российский паразитологический журнал, 2016 It is offered sanitary-parasitological and veterinary-sanitary model of preventive maintenance of parasitic diseases of people and animals which approbation has resulted in the high effect expressing in reduction of number of cases of new infections in ...
G. R. Bajramgulova +5 more
doaj
DOE/NASA wind turbine data acquisition system. Part 4: Operations and maintenance manual (Plumbrook Station) [PDF]
Preventive maintenance, calibration procedures, system verification, system operating procedures, systems software fundamentals, data base (program files), and patchboard layout are ...
Prenger, S., Tatman, T.
core +1 more source
Planning long-term maintenance for electric vehicle charging infrastructure using the Reliability Centered Maintenance (RCM) method [PDF]
, 2012 Electric vehicles (EVs) are mainly known for their advantages as emission free, energy efficient and noiseless transport, but electric mobility has never matured in the automotive market and it remains in the shadow of the internal combustion engine (ICE)
LIOCE, LUIGI
core