Results 91 to 100 of about 1,612,807 (286)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smart Preventive Maintenance of Hybrid Networks and IoT Systems Using Software Sensing and Future State Prediction. [PDF]
Sensors (Basel), 2023 Minea M, Minea VL, Semenescu A.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Optimal preventive-maintenance warranty policy for repairable products
, 2011 This paper investigates preventive-maintenance warranty (PMW) policies for repairable products. When the length of a warranty period is pre-specified, the optimal number of preventive maintenance actions, corresponding maintenance degrees, and the ...
Yeh, Ruey-huei ; 羅惠瓊; Lo, Hui-chiung
core +1 more source
Optimal Periods of Conducting Preventive Maintenance to Reduce Expected Downtime and Its Impact on Improving Reliability. [PDF]
Comput Intell Neurosci, 2022 Al-Duais FS +4 more
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Rate-of-change analysis applied to machine tool monitoring and maintenance schedules [PDF]
, 2012 In high-value manufacturing, production equipment is often calibrated on a regular basis to ensure it remains within the required absolute tolerance. However, this go/no go approach means that data relating to the rate of change of the condition of the ...
Longstaff, Andrew P. +4 more
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Preventive maintance plan for SKF Latin Trade SAS equipment
DynaThis research presents the design and implementation of the preventive and predictive maintenance plan developed for the seven polishing machines of the Swedish multinational SKF, of the LSB (Large Size Bearing) line.
Danilo Andrés González-López +1 more
doaj +1 more source
Modelling and Simulation in Engineering, 2014 The purpose of this study was to increase the quality of product by focusing on the machine efficiency improvement. The principle of the reliability centered maintenance (RCM) was applied to increase the machine reliability.
Srisawat Supsomboon +1 more
doaj +1 more source