Results 81 to 90 of about 1,612,807 (286)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Economic Design of and Control Charts with Preventive Maintenance and Increasing Hazard Rate
, 2010 [[abstract]]Develops the joint economic designs of • and S2 control charts under four operating policies to monitor the process in a situation where the occurrence of the assignable cause follows a general distribution with an increasing hazard rate. The
Huan‐Neng Chiu;Bo‐Shi Huang
core
The technical systems preventive maintenance trade-off model
Vojnotehnički Glasnik, 1996 A complex technical system preventive maintenance model based on a 'trade-off' between maximum availability and cost-effectiveness criterions was developed.
Svetomir Minić +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The modern approach to preventive maintenance of parasitic diseases
Российский паразитологический журнал, 2016 It is offered sanitary-parasitological and veterinary-sanitary model of preventive maintenance of parasitic diseases of people and animals which approbation has resulted in the high effect expressing in reduction of number of cases of new infections in ...
G. R. Bajramgulova +5 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The mathematical approach to the technical systems maintenance management
Vojnotehnički Glasnik, 1999 In this paper, the up-to-date mathematical approach to the problem of optimal management of complex technical system preventive maintenance process is presented.
Svetomir Minić
doaj +1 more source
Optimization model for production scheduling taking into account preventive maintenance in an uncertainty-based production system. [PDF]
Heliyon, 2023 Penchev P, Vitliemov P, Georgiev I.
europepmc +1 more source