Results 81 to 90 of about 435,252 (323)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research of Preventive Maintenance Task Optimization of Military Aircraft Based on S4000P

Hangkong gongcheng jinzhan, 2020
Preventive maintenance is the main measure to restore and maintain the safety and reliability of the aircraft, and its optimization as a common concern is concerned by both aircraft manufacturers and users.
NAN Yanfei, JIANG Qingxi, LIN Cong
doaj   +1 more source

Usulan Jadwal Perawatan Preventif Mesin HGF di Stasiun Puteran Pabrik Gula [PDF]

, 2008
The HGF (High Grade Fugal) Machine is one of the machines which often failed in The Sugar Factory XYZ. Brake Shoes and Belt drive are critical components of HGF Machine. The Management already used corrective maintenance policy where the maintenance only
Nugroho, Ari, Sutopo, Wahyudi, Yuniaristanto,   +2 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Preventive maintenance strategy of electric multiple unit critical equipment based on replacement repair

机车电传动, 2022
Considering that the entire electric multiple unit (EMU) needs to be withdrawn from service for carrying out preventive maintenance (PM) of the critical equipment, leading to an increase to downtime loss, the concept of replacement repair is proposed in ...
XIONG Lü, LIU Zhilong
doaj  

ANALISA PERAWATAN DAN USULAN PREVENTIVE MAINTENANCE PADA MESIN CONSTANT SPEED MIXER DI PT. KEBAYORAN WARNA PRIMA [PDF]

, 2010
ANALISA PERAWATAN DAN USULAN PREVENTIVE MAINTENANCE PADA MESIN CONSTANT SPEED MIXER DI PT.
CHRISTHOPER ALEXANDER RUMAWAS, YOSUA, ERICKNES, ERICKNES, SUYUDI, ARYO   +2 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Planning long-term maintenance for electric vehicle charging infrastructure using the Reliability Centered Maintenance (RCM) method [PDF]

, 2012
Electric vehicles (EVs) are mainly known for their advantages as emission free, energy efficient and noiseless transport, but electric mobility has never matured in the automotive market and it remains in the shadow of the internal combustion engine (ICE)
LIOCE, LUIGI
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source