Results 71 to 80 of about 7,712,805 (262)

The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure that IPTi is acceptable, that it does not ...
Alonso, Pedro, Schellenberg, David, Pool, Robert, Montgomery, Catherine, Mushi, Adiel, Schellenberg, Joanna Armstrong, Mrisho, Mwifadhi, Mshinda, Hassan, Tanner, Marcel, Mrisho Mwifadhi, Montgomery Catherine, Mushi Adiel, Tanner Marcel, Schellenberg David, Alonso Pedro, Mshinda Hassan, Schellenberg Joanna, Pool Robert   +17 more
core   +1 more source

Migraine epidemiology, comorbidities and therapeutic landscape: a national population-based study

Frontiers in Neurology
BackgroundMigraine is a leading cause of disability worldwide, yet national-level epidemiological data are often lacking, hindering public health planning.
Nirit Lev, Nirit Lev, Lihie Sheffer, Ido Peles, Emily Elefant, Emily Elefant, Gal Ifergane, Gal Ifergane   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From strategy development to routine implementation: the cost of Intermittent Preventive Treatment in Infants for malaria control. [PDF]

, 2008
BACKGROUND\ud \ud Achieving the Millennium Development Goals for health requires a massive scaling-up of interventions in Sub Saharan Africa. Intermittent Preventive Treatment in infants (IPTi) is a promising new tool for malaria control.
Alonso, Pedro, Manzi Fatuma, Schellenberg, David, Hutton Guy, Manzi, Fatuma, David Schellenberg, Tanner Marcel, Schellenberg David, Alonso Pedro, Marcel Tanner, Fatuma Manzi, Hassan Mshinda, Mshinda Hassan, Schellenberg, Joanna, Schellenberg Joanna, Pedro Alonso, Hutton, Guy, Joanna Schellenberg, Mshinda, Hassan, Tanner, Marcel, Guy Hutton   +20 more
core   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areas. [PDF]

, 2010
Anti-malarial drugs can make a significant contribution to the control of malaria in endemic areas when used for prevention as well as for treatment. Chemoprophylaxis is effective in preventing deaths and morbidity from malaria, but it is difficult to ...
Greenwood Brian, Greenwood, Brian, Brian Greenwood   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Refractory migraine

Неврология, нейропсихиатрия, психосоматика
Many patients with chronic migraine abuse symptomatic medications, have drug-induced headaches, psychiatric comorbidities and respond poorly to conventional preventive therapy.
G. R. Tabeeva, O. V. Kosivtsova, N. A. Kovalchuk, T. A. Orlyuk   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source