Results 61 to 70 of about 49,072 (180)
Revista Cubana de MedicinaEn este trabajo se comparan las enfermedades priónicas con la enfermedad de Alzheimer, tratando de dar una explicación, en el orden epidemiológico, al aumento de la incidencia de esta última, así como la similitud que se establece en el ámbito clínico ...
Edmundo Rivero Arias
doaj
Epilepsia, EarlyView.Abstract Objective New onset refractory status epilepticus (NORSE) is a rare, severe presentation of refractory status epilepticus (RSE), with approximately half of cases cryptogenic NORSE (c‐NORSE). We compared electroencephalographic (EEG) findings alongside clinical features between NORSE and RSE not meeting NORSE criteria to better understand ...
Seren Hawksworth +6 more
wiley +1 more source
Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells
Interdisciplinary Medicine, EarlyView.Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen +6 more
wiley +1 more source
Acta Neuropathologica Communications, 2018 Transmissible spongiform encephalopathies, also known as prion diseases, are a group of fatal neurodegenerative disorders affecting both humans and animals.
Fei Wang +3 more
doaj +1 more source
Journal of the Chinese Chemical Society, EarlyView.While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley +1 more source
MedisanLas enfermedades priónicas son procesos neurodegenerativos producidos por el metabolismo aberrante de una proteína priónica, que afectan a seres humanos y animales durante un período de incubación prolongado, con carácter transmisible y evolución clínica
Tamara Rubio González +1 more
doaj
Prions amplify through degradation of the VPS10P sorting receptor sortilin.
PLoS Pathogens, 2017 Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc.
Keiji Uchiyama +7 more
doaj +1 more source
Modeling localized deer removal strategies for managing chronic wasting disease
The Journal of Wildlife Management, EarlyView.We used an agent‐based model developed for chronic wasting disease (CWD) in Midwestern white‐tailed deer to assess localized deer removal strategies and how local conditions affect management outcomes. Parcel‐based and ring culling were most effective at reducing CWD prevalence and persistence, and transmission was always greater at greater deer ...
Noelle E. Thompson +5 more
wiley +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo +10 more
wiley +1 more source