Results 61 to 70 of about 44,352 (319)

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Metabolic control in patients with type 1 diabetes mellitus at the onset of primary adrenal insufficiency

Ожирение и метаболизм, 2013
Primary adrenal insufficiency is a rare disorder but it is more common in patients with type 1 diabetes mellitus (T1DM) or autoimmune thyroid diseases than in the general population.

doaj   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf, Bornstein, Stefan R., Grotemeyer, Dirk, Hamann, Lutz, Koch, Alexander, Kurt, Muhammed, Schott, Matthias, Schumann, Ralf R., Schwenke, Carsten, Zacharowski, Kai   +9 more
core   +2 more sources

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source

A Rare Case of Autoimmune Polyglandular Syndrome Type 2 in a Child With Persistent Fatigue

Global Pediatric Health, 2019
Adrenal insufficiency is a rare, potentially life-threatening condition whose diagnosis requires a high index of suspicion. Adrenal insufficiency may be primary, secondary, or tertiary with varied etiologies.
Ryan Kenneth Smith DO, Peter M. Gerrits MD   +1 more
doaj   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Genetic Aetiology of Primary Adrenal Insufficiency in Chinese Children [PDF]

BMC Medical Genomics, 2020
Abstract Background Primary adrenal insufficiency (PAI) is a life-threatening condition, and a definitive aetiological diagnosis is essential for management and prognostication. We conducted this study to investigate the genetic aetiologies of PAI in South China and explore their clinical features. Results Among the 70 children, 84.29% (59/70)
Zhuo Chang, Wei Lu, Zhu-Hui Zhao, Li Xi, Xiao-Jing Li, Rong Ye, Jin-Wen Ni, Zhou Pei, Miao-Ying Zhang, Ruo-Qian Cheng, Zhang-Qian Zheng, Cheng-Jun Sun, Jing Wu, Feihong Luo   +13 more
openaire   +6 more sources

X-linked adrenal hipoplasia congenita: clinical and follow-up findings of two kindreds, one with a novel NR0B1 mutation [PDF]

, 2015
X-linked adrenal hypoplasia congenita typically manifests as primary adrenal insufficiency in the newborn age and hypogonadotropic hypogonadism in males, being caused by mutations in NR0B1 gene.
Dias Pereira, Bernardo, Gonçalves, João, Pereira, Iris, Portugal, Jorge Ralha, Raimundo, Luísa   +4 more
core   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Fertility and pregnancy in adrenal insufficiency

Endocrine Connections
Despite the availability of adrenal hormone replacement therapy, patients with adrenal insufficiency can be affected by reduced fertility and parity.
Deirdre Green, Rosemary Dineen, Michael W O’Reilly, Mark Sherlock   +3 more
doaj   +1 more source