Results 81 to 90 of about 83,365 (272)

Clinical insights of pregnancy management, adrenal insufficiency as a possible cause of elevated TSH: a pilot study of case series

BMC Pregnancy and Childbirth, 2023
Background The upper limit for thyroid-stimulating hormone has been strictly defined for pregnancy management, at which point levothyroxine replacement therapy will been initiated.
Ken Kanazawa, Tatsuro Inaba, Shinichiro Koga, Koichiro Kuwabara   +3 more
doaj   +1 more source

Primary Adrenal Insufficiency in childhood: data from a large nationwide cohort.

Journal of Clinical Endocrinology and Metabolism, 2020
CONTEXT Primary adrenal insufficiency (PAI) is a rare and potentially life-threatening condition, poorly characterized in children. OBJECTIVE to describe causes, presentation, auxological outcome, frequency of adrenal crisis and mortality of a large ...
D. Capalbo, C. Moracas, M. Cappa, A. Balsamo, M. Maghnie, M. Wasniewska, N. Greggio, F. Baronio, C. Bizzarri, Giusy Ferro, A. di Lascio, M. Stancampiano, Sara Azzolini, G. Patti, S. Longhi, M. Valenzise, G. Radetti, C. Betterle, G. Russo, M. Salerno   +19 more
semanticscholar   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective Despite the availability of biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit, Atul Singhal, Alan Kivitz, Edit Drescher, Yoshinori Taniguchi, Rosalía Martínez Pérez, Jaclyn Anderson, Ronilda D'Cunha, Weihan Zhao, Nicholas DeVogel, Julie Parmentier, Romy Christmann, Dilek Arikan, Howard Amital   +13 more
wiley   +1 more source

Primary Adrenal Insufficiency during Immune Checkpoint Inhibitor Treatment: Case Reports and Review of the Literature

Case Reports in Oncology, 2020
As the indications and clinical use of immune checkpoint inhibitors increase, it is expected that we will face some of their less frequently reported complications.
C. Salinas, A. Renner, C. Rojas, S. Samtani, Mauricio Burotto   +4 more
semanticscholar   +1 more source

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients with Eosinophilic Granulomatosis with Polyangiitis

Arthritis &Rheumatology, Accepted Article.
Objective The Phase 3 MANDARA study demonstrated non‐inferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair, Bernhard Hellmich, Arnaud Bourdin, David R. W. Jayne, Florence Roufosse, Nader Khalidi, Lena Börjesson Sjö, Ying Fan, Christopher McCrae, Sofia Necander, Eva Rodríguez‐Suárez, Anat Shavit, Claire Walton, Peter A. Merkel, Michael E. Wechsler   +14 more
wiley   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

A Cross-sectional Study of Prevalence of Adrenal Insufficiency in Patients with Primary Autoimmune Hypothyroidism in a Tertiary Hospital, India

APIK Journal of Internal Medicine
Objectives: This study aimed to assess the prevalence of adrenal insufficiency in patients with primary hypothyroidism who continued to be symptomatic despite adequate biochemical correction of hypothyroidism with synthetic levothyroxine.
Paramjit Kaur Saini, Jubbin Jagan Jacob, Navjot Singh   +2 more
doaj   +1 more source

Pediatric Primary Adrenal Insufficiency: A 21-year Single Center Experience

Journal of Clinical Research in Pediatric Endocrinology, 2020
Objective: Primary adrenal insufficiency (PAI) is a rare but potentially life-threatening condition. In childhood, PAI is usually caused by monogenic diseases.
Emine Çamtosun, İ. Dündar, A. Akıncı, Leman Kayaş, Nurdan Çiftçi   +4 more
semanticscholar   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, EarlyView.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source