Results 81 to 90 of about 4,961,010 (265)

Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients

Frontiers in Endocrinology, 2021
Purpose This study aimed to determine the relationships among gut microbiota, primary aldosteronism (PA), and related metabolic disorders. Methods The study enrolled 13 PA patients, 26 sex-matched primary hypertension patients, and 26 sex-matched healthy
Yu Liu, Q. Jiang, Zhi-Hong Liu, S. Shen, J. Ai, Yuchun Zhu, Liang Zhou   +6 more
semanticscholar   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Advances in the biochemical diagnostics of primary aldosteronism: from immunoassays to steroidomics and proteomics

Frontiers in Endocrinology
Primary aldosteronism is the most common cause of secondary hypertension, yet most cases remain unrecognized and left without optimal treatment. The diagnostic inertia may be attributed to the lack of specific symptoms, insufficient awareness among ...
Alicja Szatko, Alicja Szatko, Alicja Szatko, Agata Toboła, Henrik Falhammar, Henrik Falhammar, Wojciech Zgliczyński, Piotr Glinicki, Piotr Glinicki   +8 more
doaj   +1 more source

International histopathology consensus for unilateral primary aldosteronism.

Journal of Clinical Endocrinology and Metabolism, 2020
OBJECTIVE Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). CONTEXT Unilateral PA is the most common surgically-treated form of hypertension.
T. Williams, C. Gomez-Sanchez, W. Rainey, T. Giordano, Alfred K. Lam, A. Marker, O. Mete, Y. Yamazaki, M. Zerbini, F. Beuschlein, F. Satoh, J. Burrello, Holger Schneider, J. Lenders, P. Mulatero, I. Castellano, T. Knösel, M. Papotti, W. Saeger, H. Sasano, M. Reincke   +20 more
semanticscholar   +1 more source

ClC‐2 Contributes to Hypotonicity‐Induced Adrenal Aldosterone Secretion

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim The zona glomerulosa (ZG) of the adrenal cortex regulates blood pressure and electrolyte homeostasis through aldosterone production. In ZG cells, potassium and angiotensin II (Ang II) trigger calcium oscillations that drive aldosterone synthesis.
Marina Volkert, Hoang An Dinh, Ute I. Scholl, Gabriel Stölting   +3 more
wiley   +1 more source

Primary Aldosteronism and Pregnancy

Kidney & Blood Pressure Research, 2020
Objective: Primary aldosteronism (PA) may present at younger age and may thus complicate pregnancy. Our aim was to identify female patients in whom PA was diagnosed after pregnancy complicated with hypertension and to analyze possible hypertension ...
Tomáš Zelinka, Ondřej Petrák, Ján Rosa, Robert Holaj, Branislav Štrauch, Jiří Widimský Jr.   +5 more
doaj   +1 more source

Gitelman and Bartter Syndrome in a Patient With Morbid Obesity: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT We present a case study of a 34‐year‐old man with morbid obesity and a suspected Bartter–Gitelman spectrum tubulopathy (without genetic confirmation), weighing 135 kg, and with a BMI of 42.5 kg/m2, who was referred to the metabolic and bariatric surgery department due to morbid obesity to address abnormal electrolyte levels.
Solmaz Hasani, Alireza Rezapanah, Tooraj Zandbaf, Mohammad Javad Ghamari, Narges Mesbah   +4 more
wiley   +1 more source

Aldosterone and Cardiovascular Risk Across the Lifespan

Metabolites
Aldosterone excess, particularly in the context of primary aldosteronism, is associated with adverse cardiovascular outcomes. Historically considered a condition of resistant hypertension with hypokalaemia, patients with primary aldosteronism often ...
Roshan A. Ananda, Trevor A. Mori, Jun Yang   +2 more
doaj   +1 more source

The results of immunohistochemical study of antibodies to CYP11B2 in primary hyperaldosteronism

Ожирение и метаболизм, 2021
Background: Aldosterone-producing adrenocortical adenoma (APA) is responsible for the majority of cases clinically diagnosed as primary aldosteronism. Aldosterone synthase (CYP11B2) is one of the enzymes that play essential roles in aldosterone synthesis
N. Yu. Romanova, L. S. Selivanova, N. M. Platonova, D. G. Beltsevich, E. A. Troshina   +4 more
doaj   +1 more source

Primary Aldosteronism: Novel Insights

Current Hypertension Reviews, 2020
Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher than hypertensive individuals with equal blood pressure levels. Objectives: The study aimed to thoroughly present and critically discuss the novel insights into the field of ...
Stavropoulos, K., Imprialos, K., Papademetriou, V., Faselis, C., Tsioufis, K., Dimitriadis, K., Doumas, M.   +6 more
openaire   +3 more sources