Results 91 to 100 of about 4,431,933 (293)

Current Landscape and Evolving Therapies for Primary Biliary Cholangitis

Cells
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disorder characterized by progressive cholestatic that, if untreated, can progress to liver fibrosis, cirrhosis and liver decompensation requiring liver transplant. Although the pathogenesis
S. Fiorucci, G. Urbani, C. Di Giorgio, M. Biagioli, E. Distrutti   +4 more
semanticscholar   +1 more source

Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up [PDF]

, 2000
Background/Aims: Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, few data exist on the long-term ...
Paumgartner, Gustav, Pape, G. R., Rau, Horst, Pape, Gerd R., Rau, H., Paumgartner, G., Gerbes, Alexander L., Schildberg, F. W., Rust, C., Beuers, Ulrich, Haller, M., Krämling, H., Schildberg, Friedrich Wilhelm, Haller, Matthias, Gerbes, A. L., Krämling, Hans-Jörg, Beuers, U., Rust, Christian   +17 more
core   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Obeticholic Acid for Primary Biliary Cholangitis

Biomedicines, 2022
Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease that may progress to fibrosis and/or cirrhosis. Treatment options are currently limited.
Annarosa Floreani, Daniela Gabbia, Sara De Martin   +2 more
doaj   +1 more source

The overlap with metabolic dysfunction‐associated steatotic liver disease negatively affects outcomes of primary biliary cholangitis

Alimentary Pharmacology and Therapeutics
The relationship between primary biliary cholangitis (PBC) and metabolic dysfunction‐associated steatotic liver disease, and its impact on treatment response and prognosis, remains underexplored.
M. Hernández-Pérez, D. Riado, E. Peña, Carmen Méndez, F. Pinedo, Paloma Ramos, Pilar Castillo, Míriam Romero, C. Fernández-Rodríguez, A. Olveira   +9 more
semanticscholar   +1 more source

Emerging therapeutic strategies in the fight against primary biliary cholangitis [PDF]

, 2023
The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), pre-viously known as primary biliary cirrhosis, is a chronic choles-tatic autoimmune disease of the intrahepatic bile ducts asso-ciated ...
Medford, A, Little, A, Abigail Medford, Chakraborty, S, Childs, J, Glaser, S, Ashleigh Little, Medford, Abigail, Childs, Jonathan, Chakraborty, Sanjukta, Glaser, Shannon, Alpini, G, Sanjukta Chakraborty, Baiocchi, L, Gianfranco Alpini, Little, Ashleigh, Baiocchi, Leonardo, Alpini, Gianfranco, Leonardo Baiocchi, Shannon Glaser, Jonathan Childs   +20 more
core   +1 more source

Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications

Frontiers in Cell and Developmental Biology
Mesenchymal stem cells (MSCs) have emerged as promising therapeutic candidates for a wide range of intrahepatic and extrahepatic biliary diseases. However, their clinical application remains limited by an incomplete understanding of underlying mechanisms
Meng-jiao Li, Meng-jiao Li, Wei Zhao, Cai-yang Li, Cai-yang Li, Yan-ling Li, Yan-ling Li, Shi-hui Ren, Jia-jia Li, Jia-jia Li, Ling Qiu, Cheng-wei Yang, Fang-yi Fan, Fang-yi Fan, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Hao Yao   +18 more
doaj   +1 more source

Evaluation and Management of Pruritus in Primary Biliary Cholangitis.

Clinical Liver Disease, 2022
Chronic pruritus is a classic symptom in patients with primary biliary cholangitis. It affects up to two-thirds of patients in the course of the disease.
M. Düll, Andreas E. Kremer
semanticscholar   +1 more source

Primary Biliary Cholangitis With Incomplete Response to Conventional Therapies But Had Complete Response to Baricitinib: A Case Report

Case Reports in Hepatology
Primary biliary cholangitis is a progressive disease with complications such as liver cirrhosis and hepatocellular carcinoma, and the treatment goal is to delay its progression.
Gi Eun Kim, Mariam Imran, Sherif Mostafa, Yasser Kamel   +3 more
doaj   +1 more source

The changing faces of cholangitis [version 1; referees: 2 approved]

F1000Research, 2016
A variety of diseases are included under the umbrella term ‘cholangitis’, including hepatobiliary diseases with an autoimmune pathogenesis (such as primary sclerosing cholangitis, primary biliary cholangitis, and IgG4-associated sclerosing cholangitis ...
Sum P. Lee, Joseph R. Roberts, Rahul Kuver   +2 more
doaj   +1 more source