Results 81 to 90 of about 48,035 (283)

Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)–exposed versus unexposed systemic lupus erythematosus (SLE) pregnancies within the multicenter prospective Lupus in Pregnancy (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Clinics in Canada, South Korea, Peru,
Reem Farhat, Maria del Carmen Zamora‐Medina, Sang‐Cheol Bae, Megan R. W. Barber, Ann E. Clarke, Paul R. Fortin, Zahi Touma, Carl A. Laskin, Isabelle Malhamé, Giada Sebastiani, Christine Peschken, Manuel F. Ugarte‐Gil, Alexandra Legge, Sasha Bernatsky, Évelyne Vinet   +14 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Primary biliary cholangitis: Diagnosis and treatment

Liver Research, 2018
Primary biliary cholangitis (PBC) is an autoimmune disease that causes progressive destruction of the intrahepatic bile ducts. Although the pathogenesis of PBC is not completely understood, it is characterized by cholestatic inflammation resulting in a ...
Michael Chew, Christopher L. Bowlus
doaj   +1 more source

Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis

Future Science OA, 2020
Aim: To assess the ability of signature metabolites alone, or in combination with the model for end-stage liver disease-Na (MELD-Na) score to predict mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing ...
Ayse L Mindikoglu, Cristian Coarfa, Antone R Opekun, Vijay H Shah, Juan P Arab, Konstantinos N Lazaridis, Nagireddy Putluri, Chandrashekar R Ambati, Matthew J Robertson, Sridevi Devaraj, Prasun K Jalal, Abbas Rana, John A Goss, Thomas C Dowling, Matthew R Weir, Stephen L Seliger, Jean-Pierre Raufman, David W Bernard, John M Vierling   +18 more
doaj   +1 more source

Hepcidin is an antibacterial, stress-inducible peptide of the biliary system. [PDF]

PLoS ONE, 2011
BACKGROUND/AIMS: Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism.
Pavel Strnad, Peggy Schwarz, Maria C D Rasenack, Ozlem Kucukoglu, Rayan I Habib, Dominik Heuberger, Robert Ehehalt, Michael W Müller, Adolf Stiehl, Guido Adler, Hasan Kulaksiz   +10 more
doaj   +1 more source

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. [PDF]

, 2018
BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia.
Bao, X, Brito, H, Moura-Santos, P, Oliveira, A, et al., Palmela, C, Ruiqi, H, Silva, J, Torres, J   +7 more
core   +1 more source

Liver transplantation [PDF]

, 1979
Human liver transplantation, which was first performed in man in Denver 15 years ago, has finally come of age in the past 2 years. The 1 year survival has improved from 28 per cent to 50 per cent in the recent Denver Second Series.
Koep, LJ, Starzl, TE, Terblanche, J
core   +1 more source

A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome

Journal of Translational Autoimmunity, 2020
Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap.
Benedetta Terziroli Beretta-Piccoli, Luca Mazzucchelli, Chiara Taiana, Giuseppe Mossi, Corrado Usai, Diego Vergani, Giorgina Mieli-Vergani   +6 more
doaj   +1 more source

Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in CholestasisSummary

Cellular and Molecular Gastroenterology and Hepatology
Biliary fibrosis is seen in cholangiopathies, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). In PBC and PSC, biliary fibrosis is associated with worse outcomes and histologic scores.
Ludovica Ceci, Eugenio Gaudio, Lindsey Kennedy   +2 more
doaj   +1 more source

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]

, 2019
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D, Arcidiacono, Pg, Capurso, G., Cardinale, V, Carpino, G, Doglioni, C, Gaudio, E, Pedica, F, Petrone, Mc, Severi, C, Zaccari, P   +10 more
core   +1 more source