Results 81 to 90 of about 4,431,933 (293)

A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary, Ghaith Noaiseh, Julie Frantsve‐Hawley, Frederick B. Vivino, Jennifer A. McCombe, Shamik Bhattacharyya, E. Sherwood Brown, Andrew R. Carey, Robert Fox, Thomas Grader‐Beck, Janet E. Lewis, Stephen Maitz, Steven Mandel, Astrid Rasmussen, George Sarka, R. Hal Scofield, Daniel J. Wallace, Rochelle Zak, Kristie Cox, Katherine M. Hammitt, Steven Carsons, Nancy Carteron   +21 more
wiley   +1 more source

Familial primary biliary cirrhosis and autoimmune cholangitis

, 2002
: Aim. Autoimmune cholangitis has been proposed as a separate disease entity from primary biliary cirrhosis without serum antimitochondrial antibodies.
AGARWAL K., WATT F. E., JONES D. E. J., BURT A. D., BASSENDINE M. F., FLOREANI, ANNAROSA   +5 more
core   +2 more sources

Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis

Nature Communications
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by multilineage immune dysregulation, which subsequently causes inflammation, fibrosis, and even cirrhosis of liver.
C. Jin, Penglei Jiang, Zhaoru Zhang, Yingli Han, Xue-Song Wen, Lin-Xin Zheng, Wei Kuang, Jiang-Shan Lian, Guodong Yu, Xin-Ling Qian, Yue Ren, M. Lu, Lingling Xu, Weixin Chen, Ji-Yang Chen, Yu-Wei Zhou, Jinxia Xin, Ben Wang, Xi Jin, Pengxu Qian, Yida Yang   +20 more
semanticscholar   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Farnesoid X receptor agonist tropifexor attenuates cholestasis in a randomised trial in patients with primary biliary cholangitis

JHEP Reports, 2022
Background & Aims The safety, tolerability, and efficacy of the non-bile acid farnesoid X receptor agonist tropifexor were evaluated in a phase II, double-blind, placebo-controlled study as potential second-line therapy for patients with primary biliary ...
C. Schramm, H. Wedemeyer, A. Mason, G. Hirschfield, C. Levy, K. Kowdley, P. Milkiewicz, E. Janczewska, E. S. Malova, J. Sanni, P. Koo, Jin Chen, Subhajit Choudhury, L. Klickstein, M. Badman, David Jones   +15 more
semanticscholar   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

Jaundice, hepatosplenomegaly, and portal lymphadenopathy in a middle‐aged female: Is it lymphoma?

JGH Open, 2020
Primary biliary cholangitis is a rare liver disease which often progresses to cirrhosis. It can be difficult to diagnose as patients are often asymptomatic initially or merely complain of fatigue or pruritus.
Alexander T Elford, Jeremy P Dwyer, Scott B Fanning   +2 more
doaj   +1 more source

Primary Biliary Cholangitis with Associated Raynaud Syndrome Treatment Outcome: a Case Report [PDF]

Primary biliary cholangitis is an autoimmune liver disease, which is less common than viral hepatitis and fatty liver disease, but in recent decades there has been a steady increase in the PBC occurrence.
Ainur Doszhan, Galiya Shaimardanova, Nina Tostanovskaya, Gulsara Imambayeva, Assyltay Nauryzbayeva, Larissa Kozina   +5 more
core   +2 more sources

Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)–exposed versus unexposed systemic lupus erythematosus (SLE) pregnancies within the multicenter prospective Lupus in Pregnancy (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Clinics in Canada, South Korea, Peru,
Reem Farhat, Maria del Carmen Zamora‐Medina, Sang‐Cheol Bae, Megan R. W. Barber, Ann E. Clarke, Paul R. Fortin, Zahi Touma, Carl A. Laskin, Isabelle Malhamé, Giada Sebastiani, Christine Peschken, Manuel F. Ugarte‐Gil, Alexandra Legge, Sasha Bernatsky, Évelyne Vinet   +14 more
wiley   +1 more source

Some features of sclerotic processes in the walls of the bile ducts and gall bladder in chronic bile tract diseases (a review of literature)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
The article presents the results of studies of variants of the development of sclerotic changes in the liver tissue, intrahepatic and extrahepatic ducts, as well as the walls of the gallbladder associated with various chronic diseases of the biliary ...
M.G. Fedorova, E.V. Komarova, N.O. Tsyplikhin   +2 more
doaj   +1 more source