Results 71 to 80 of about 4,431,933 (293)

Autotaxin: A Potential biomarker for primary biliary cholangitis

Heliyon
Background: In some patients especially those AMA negative, the diagnosis may be a challenge requiring liver biopsy. This study determined whether autotaxin, a secreted lysophospholipase D encoded by the exonucleotide pyrophosphatase phosphodiesterase 2 ...
Yifei Yang, Bingqian Liu, Bo Zang, Qixuan Liu, Chenyang Zhao, Yuan Yao, Bin Liu   +6 more
doaj   +1 more source

Primary biliary cholangitis: symptoms, diagnosis and treatment

, 2017
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic but progressive disease that, over many years, causes damage to bile ducts, leading to cholestasis and, in some patients, cirrhosis.
Gerri Mortimore, Mortimore, Gerri
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Double blind controlled trial of D-penicillamine in patients with primary biliary cirrhosis. [PDF]

, 1985
One hundred and eighty nine patients with primary biliary cirrhosis were entered into a double blind, placebo controlled randomised trial starting in January 1978 to assess the therapeutic value of d-penicillamine 1200 mg daily.
Tygstrup, Niels, Williams, Roger, Rodés, J., Ranek, L., Neuberger, J., Christensen, E., Caballeria Rovira, Joan, Portmann, B.   +7 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Long-term endoscopic management for primary recurrent pyogenic cholangitis

Journal of Digestive Endoscopy, 2014
Background: Primary recurrent pyogenic cholangitis (RPC) is characterized by relentless suppurative cholangitis in those with a suspected parasitic injury of the biliary tree.
James L. Buxbaum, Christianne J. Lane, Karen C. Bagatelos, James W. Ostroff   +3 more
doaj   +1 more source

COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls

American Journal of Gastroenterology
INTRODUCTION: Obeticholic acid (OCA) treatment for primary biliary cholangitis (PBC) was conditionally approved in the phase 3 POISE trial. The COBALT confirmatory trial assessed whether clinical outcomes in patients with PBC improve with OCA therapy ...
Kris V. Kowdley, G. Hirschfield, Charles Coombs, E. Malecha, Leona Bessonova, Jing Li, Nuvan S. Rathnayaka, G. Mells, David Jones, P. Trivedi, Bettina Hansen, Rachel Smith, J. Wason, S. Hiu, D. Kareithi, A. L. Mason, C. Bowlus, Kate Muller, Marco Carbone, Marina Berenguer, P. Milkiewicz, F. Adekunle, A. Villamil   +22 more
semanticscholar   +1 more source

Management of Autoimmune Liver Diseases after Liver Transplantation

Transplantology, 2021
Autoimmune liver diseases are characterized by immune-mediated inflammation and eventual destruction of the hepatocytes and the biliary epithelial cells. They can progress to irreversible liver damage requiring liver transplantation.
Romelia Barba Bernal, Esli Medina-Morales, Daniela Goyes, Vilas Patwardhan, Alan Bonder   +4 more
doaj   +1 more source