Results 21 to 30 of about 48,450 (199)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Medical Management of Chronic Cholestatic Liver Diseases

Canadian Journal of Gastroenterology, 2000
The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures ...
Andrea A Gossard, Keith D Lindor
doaj   +1 more source

Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete

BMC Gastroenterology, 2002
Background An increased prevalence of coeliac disease in patients with primary biliary cirrhosis has been recently reported. However, in other studies the association has not been confirmed.
Dimoulios Philippos, Koulentaki Mary, Tzardi Maria, Niniraki Maria, Drygiannakis Dimitrios, Roussomoustakaki Maria, Chatzicostas Costantinos, Mouzas Ioannis, Kouroumalis Elias   +8 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Unilateral Trigeminal Sensory Neuropathy with Sjögren’s Syndrome with Liver and Renal Impairment

Neurology International, 2021
Liver and renal involvement is a rare event in Sjögren’s syndrome. Sjögren’s syndrome is characterized by the progressive immune-mediated destruction of epithelial tissues of the salivary and lacrimal glands.
Kana Ozasa, Noboru Noma, Jumi Nakata, Yoshiki Imamura   +3 more
doaj   +1 more source

Prevalence of IgA Antibodies to Endomysium and Tissue Transglutaminase in Primary Biliary Cirrhosis

Canadian Journal of Gastroenterology, 2000
The association between celiac disease and primary biliary cirrhosis has been described in several case reports and small screening studies, with varying prevalence rates.
Helen R Gillett, Karen Cauch-Dudek, E Jenny L Healthcote, Hugh J Freeman   +3 more
doaj   +1 more source

Primary bilial cholangitis: a new definition of the disease, current aspects of diagnosis and treatment. Literature review

Клинический разбор в общей медицине, 2023
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by T-lymphocyte-mediated damage to intrahepatic biliary epithelial cells and the presence of a specific serological marker, antimitochondrial antibodies ...
Dmitry I. Trukhan
doaj   +1 more source

Cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome

Annals of Hepatology, 2015
Cutaneous amyloidosis is a rare disease characterized by the deposition of amyloid in the dermis. It can be primary or secondary, depending on associated diseases. It has been linked to various autoimmune diseases, including primary biliary cirrhosis. We
Emmanuel I. González-Moreno, Carlos R. Cámara-Lemarroy, David O. Borjas-Almaguer, Sylvia A. Martínez-Cabriales, Jonathan Paz-Delgadillo, Rodrigo Gutiérrez-Udave, Ana S. Ayala-Cortés, Jorge Ocampo-Candiani, Carlos A. Cortéz-Hernández, Héctor J. Maldonado-Garza   +9 more
doaj   +1 more source

Twelve-Year-Old Girl with Primary Biliary Cirrhosis

Case Reports in Pediatrics, 2012
Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic liver disease of autoimmune etiology. The initial presentation of PBC is varies from asymptomatic, abnormal liver biochemical tests to overt cirrhosis.
Ivana Kitic, Aleksandra Boskovic, Ivica Stankovic, Dragan Prokic   +3 more
doaj   +1 more source