Results 71 to 80 of about 25,833,379 (292)

Advances in Pathobiology of Primary Central Nervous System Lymphoma

Chinese Medical Journal, 2017
Objective: Primary central nervous system lymphoma (PCNSL) is a specific type of non-Hodgkin lymphoma with poor prognosis. The rare incidence of this disease and difficulty to obtain sufficient tissue material impede deep research into PCNSL.
Xue-Liang Yang, Yuan-Bo Liu
doaj   +1 more source

Klinefelter's syndrome and primary central nervous system lymphoma

, 1990
Klinefelter's syndrome is known to be associated with various malignancies including male breast cancer and germ cell tumour. We report a patient with Klinefelter's syndrome who developed a primary B-cell lymphoma of the central nervous system (CNS).
Ho, F, Collins, R, Liang, R, Ma, J, Choy, D, Woo, E   +5 more
core   +1 more source

Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis [PDF]

, 2011
We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin's lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003-12/2007
Pels, H, Linnebank, M, Herrlinger, U, Schmidt-Wolf, Ingo G H, Pels, Hendrik, Vogt-Schaden, M, Vogt-Schaden, Marlies, Wätzel, Luise, Schlegel, Uwe, Schmidt-Wolf, Ingo G. H., Egerer, G, Batchelor, Tracy T, International Primary CNS Lymphoma Collaborative Group (IPCG), Batchelor, Tracy T., Reiser, Marcel, Reiser, M, Lamprecht, M, Kowoll, Annika, Schmidt-Wolf, IG, Wätzel, L, Engert, A, Egerer, Gerlinde, Patrij, K, Schackert, G, Batchelor, TT, Schackert, Gabriele, Kowoll, A, Linnebank, Michael, Schlegel, U, Herrlinger, Ulrich, Patrij, Katrin, Engert, Andreas, Lamprecht, Monika   +32 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary Central Nervous System Lymphoma

Cancer Cell, 2017
SUMMARY Primary central nervous system lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR) signaling. Ibrutinib, a BTK inhibitor, targets BCR signaling and is particularly active in lymphomas with BCR and MYD88 mutations. We performed
M. Lionakis, K. Dunleavy, M. Roschewski, B. Widemann, J. Butman, R. Schmitz, Yandan Yang, D. Cole, C. Melani, C. Higham, Jigar V. Desai, M. Ceribelli, Lu Chen, Craig J. Thomas, R. Little, J. Gea-Banacloche, S. Bhaumik, M. Stetler-stevenson, S. Pittaluga, E. Jaffe, John D Heiss, N. Lucas, S. Steinberg, L. Staudt, W. Wilson   +24 more
semanticscholar   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Primary Central Nervous System Lymphoma Mimicking Neuro-Behçet’s Disease

Cerrahpaşa Medical Journal
  Cite this article as: Türk BG, Emre DH, Asan F, Kızılkılı. O, Saip S. Primary central nervous system lymphoma mimicking neuro-Behçet’s disease. Cerrahpaşa Med J 2026, 50, 0049, doi: 10.5152/cjm.2026.26049.    
Bengi Gül Türk, Doğukan Hazar Emre, Furkan Asan, Osman Kızılkılıç, Sabahattin Saip   +4 more
doaj   +1 more source

Central nervous system lymphoma: iconographic essay [PDF]

, 2015
The authors illustrate the present pictorial essay about central nervous system lymphoma with magnetic resonance images obtained in their institution over the past 13 years. Some of the main radiological findings in primary and secondary presentations of
Nascimento, Felipe Barjud Pereira do, Reis, Fabiano, Schwingel, Ricardo   +2 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source