Results 131 to 140 of about 78,237 (351)

Primary cilia in gastrointestinal stromal tumors

Neoplasma, 2014
The primary cilium is a solitary, sensory, non-motile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cells. The objective of the current pilot study was to conduct an investigation of presence and frequency of cilia in gastrointestinal stromal tumors (GIST).The presence of primary cilia in ...
J, Dvorak, V, Sitorova, D Hadzi, Nikolov, A, Filipova, A, Ryska, B, Melichar, I, Richter, D, Buka, J, Mokry, S, Filip, J, Petera   +10 more
openaire   +3 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal

Stem Cell Reports, 2016
Summary: Regeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative ...
Nur Hayati Jaafar Marican, Sara B. Cruz-Migoni, Anne-Gaëlle Borycki   +2 more
doaj   +1 more source

Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery

Advanced Science, EarlyView.
This work introduces a frequency‐encoded, reconfigurable acoustofluidic system that overcomes the low throughput and poor selectivity of conventional micro‐delivery methods. By exploiting discrete microbubble resonances to program adaptive microvortex modes, the platform enables real‐time switching and selective guidance of microscale payloads through ...
Lei Wang, Yiqiang Wu, Yiyang Tang, Hui Wei, Tianshi Lyu, Xin Zhang, Tian‐Yun Huang   +6 more
wiley   +1 more source

Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia

Frontiers in Aging Neuroscience, 2016
The primary cilia of forebrain neurons assemble around birth and become enriched with neuromodulatory receptors. Our understanding of the permanence of these structures and their associated signaling pathways in the aging brain is poor, but they are ...
Sarah eGuadiana, Alexander eParker, Gileno F Filho, Ashton eSequeira, Susan eRowland, Gerry eShaw, Ron eMandel, Thomas C Foster, Ashok eKumar, Matthew eSarkisian   +9 more
doaj   +1 more source

Confocal microscopy images (CZI files) of human chondrocytes of different resolutions and magnifications with stained nuclei and primary cilia

, 2023
Kai Budde, Simone Krueger, Clemens Sehlke, Heiko Lemcke   +3 more
openalex   +2 more sources

Dendritic Nano‐Based Slippery Coating by Synergistic Mechanical and Electrostatic Interactions with Persistent and Exceptional Combats Thrombosis

Advanced Science, EarlyView.
A novel dendritic nano‐based slippery coating (DNSC), fabricated by encapsulating carboxyl silicone oil within amino dendritic silica nanoparticles and co‐embedding them in an epoxy resin matrix. The dendritic architecture enhances nanoparticle dispersion in the matrix and establishes mechanical interlock.
Shu Zhang, Yao Shen, Juan Liu, Qing Zeng, Yunze Ma, Shuping Chen, Taiyu Nan, Xiaoying Qiu, Jiayi Yu, Tao Fan, Guozhi Huang, Jihua Zou, Chengduan Yang   +12 more
wiley   +1 more source

Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechanotransduction [PDF]

, 2023
Mariana Moraes de Lima Perini, Julie N. Pugh, Elizabeth Scott, Karan Bhula, Austin Chirgwin, Olivia N. Reul, Nicolas F. Berbari, Jiliang Li   +7 more
openalex   +1 more source

Mimicking Life: Autonomous Oscillating Artificial Cilia Driven by Chemical Power

Advanced Intelligent Systems, EarlyView.
The synthesis and motion analysis of chemically actuated, individually autonomous artificial cilia are presented. Driven by an internal chemical reaction, the self‐driven individual cilia require no external stimuli. They undergo periodic oscillatory motion with a 3D beat pattern and exhibit chemotactic shifts, reminiscent of biological systems.
Rajata Suvra Chakrovorty, Yaqeen Salatneh Ashqer, Suzanne Ahmed   +2 more
wiley   +1 more source

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source