Late Holocene moisture variability in Arctic Alaska from chitin δ18O
Boreas, EarlyView.Amplified warming in the Arctic has resulted in reduced sea‐ice extent, which can impact regional climate dynamics. Elucidating past moisture variability in response to changing temperatures and sea‐ice conditions can offer insight into how anthropogenic climate change may impact Arctic areas such as the Alaskan North Slope in the future. We contribute
Briana A. Edgerton, Melissa L. Chipman
wiley +1 more source
AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas
Brain Pathology, EarlyView.Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (ADAPTR) recommendations for ependymomas in resource‐restrained settings (RL = resource level; created in BioRender). Abstract Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults.
Laveniya Satgunaseelan +13 more
wiley +1 more source
When G Protein-Coupled Receptor Signaling Meets the Primary Cilium: Implications for Sonic Hedgehog Signaling. [PDF]
BioessaysKim SE.
europepmc +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease. [PDF]
Proc Natl Acad Sci U S AUribe-Cano S, Kottmann AH.
europepmc +1 more source
Identification of drug repurposing candidates for the treatment of polycystic kidney disease
British Journal of Pharmacology, EarlyView.Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer +9 more
wiley +1 more source
Bioinformatics analyses of the proteome of <i>Holothuria tubulosa</i> coelomic fluid and the first evidence of primary cilium in coelomocyte cells. [PDF]
Front ImmunolLa Paglia L +9 more
europepmc +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Several benign, inflammatory and malignant lesions can present as iris or anterior chamber masses, including iris naevi, cysts, adenomas, leiomyomas, nodules, vascular tumours, melanomas, metastases, as well as iris and pigment epithelium adenocarcinomas. Fortunately, benign iris lesions are much more common than malignant tumours and many can
Charles N. J. McGhee +3 more
wiley +1 more source
Does the primary cilium elongation play a role in urine concentration? [PDF]
Kidney Res Clin PractKwon TH.
europepmc +1 more source
Financially Coerced ‘Self‐Produced’ Child Sexual Exploitation Material: Narratives of Accountability
Child &Family Social Work, EarlyView.ABSTRACT Perpetrators financially coerce children to ‘self‐produce’ child sexual exploitation material (CSEM). A harmful dominant narrative has historically blamed victims by framing this form of child sexual exploitation as ‘children engaging in sex work’ obfuscating the tactics of perpetrators.
Genevieve Bloxsom +4 more
wiley +1 more source