Results 261 to 270 of about 18,376 (272)
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Depletion of primary cilium in acral melanoma
Journal of Cutaneous Pathology, 2019AbstractBackgroundA eukaryotic cell's primary cilium (PC) is critical for cell signaling, migration and homeostasis. Primary cilium dysfunction has been demonstrated in several malignancies, but whether primary cilia loss occurs in acral melanoma has remained unknown.
Nick R. Love +3 more
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The PCM–basal body/primary cilium coalition
Seminars in Cell & Developmental Biology, 2010The centrosome is an organelle that acts as a microtubule-organizing center (MTOC) throughout the cell cycle. Within the centrosome are often two components that each have an ability to organize microtubule structures: the centriole that has the potential to function as a basal body and nucleate a cilium or a flagellum and a mass of protein material ...
Joanna J, Moser +3 more
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Primary Cilium in CO25 Cell Line
2003A few variety of cell type contain a primary cilium. Also the biological function(s) of primary cilia within such cell types are largely unknown. CO25 myoblast cell lines were cultured then they were stained with anti Glu- and Tyr- tubulin in this study. Glu-tubulin rich microtubules were only rarely seen in the cells.
Zeytinoğlu, Melih, Ocak, HY
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Routes and machinery of primary cilium biogenesis
Cellular and Molecular Life Sciences, 2017Primary cilia are solitary, microtubule-based protrusions of the cell surface that play fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary cilia dysfunction results in a long list of developmental and degenerative disorders that combine to give rise to a large spectrum of human diseases affecting almost any major body ...
Miguel Bernabé-Rubio, Miguel A. Alonso
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Akt regulates primary cilium dynamics
Science Signaling, 2016Activated Akt functions at the basal body of primary cilia, a hub for cellular signaling.
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Vertebrate Smoothened functions at the primary cilium
Nature, 2005The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal transduction. Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium.
Kevin C, Corbit +5 more
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A Tour de force of primary cilium biogenesis
Nature Reviews Molecular Cell Biology, 2021Elif Nur Firat-Karalar brings to our attention the early works by Sergei Sorokin that paved the way for research into the biogenesis and function of primary cilia.
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Membrane Trafficking Decisions Regulate Primary Cilium Formation
Trends in Cell Biology, 2019Rab11 and its interacting partners play a crucial role in primary cilia assembly in mammalian cells. A recent study (Walia et al., Dev. Cell, 2019) describes an as yet unexplored role for one of the Rab11 binding proteins, WDR44, in negatively regulating ciliary trafficking in concert with Akt.
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