Results 41 to 50 of about 1,658,836 (295)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tailoring inquiry for young scientists: investigating the impact of a DI PBL model on elementary students’ curiosity in biodiversity learning

Cogent Education
This study examined the impact of a Differentiated Instruction–Problem-Based Learning (DI–PBL) model on elementary students’ curiosity in biodiversity lessons.
Idam Ragil Widianto Atmojo, Dwi Yuniasih Saputri, Matsuri Matsuri, Roy Ardiansnyah, Fadhil Purnama Adi, Burhan   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Kahoot-Based Teams Games Tournament in Developing Students' Mathematical Critical Thinking

Profesi Pendidikan Dasar
Students’ low mathematical critical thinking skills, as shown by the 2022 PISA results and studies, suggest that traditional teaching methods may inadequately develop these abilities.
Lilik Mustofiyah, Sutama Sutama, Yulia Maftuhah Hidayati, Murfiah Dewi Wulandari   +3 more
doaj   +1 more source

Predicting copper-polymetallic deposits in Kalatag using the weight of evidence model and novel data sources

Open Geosciences, 2023
The Kalatag Ore Cluster Area, located in the Eastern Tianshan metallogenic belt of Xinjiang, stands out as a notable copper polymetallic mineralization zone, recognized for its diverse ore types and untapped potential.
Xi Wei, Ping YuanYe, Tao JinTao, Liu Chaoyang, Shen Junru, Zhang YaWen   +5 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

AUGMENTED REALITY MEDIA FOR LEARNING ELECTRICAL CIRCUITS: ENHANCING SCIENCE PROCESS SKILLS AND STUDENTS’ ACHIEVEMENT

Jurnal Eduscience
Purpose—The study aims to develop Android-based augmented reality (AR) instructional media for teaching electrical circuits, enhancing students' science process skills and learning outcomes.
Nendi Niati, Rahayu Condro Murti, Woro Sri Hastuti   +2 more
doaj   +1 more source