Results 81 to 90 of about 4,151,372 (299)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Desalination Processes’ Efficiency and Future Roadmap

Entropy, 2019
For future sustainable seawater desalination, the importance of achieving better energy efficiency of the existing 19,500 commercial-scale desalination plants cannot be over emphasized.
Muhammad Wakil Shahzad, Muhammad Burhan, Doskhan Ybyraiymkul, Kim Choon Ng   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Ion sputter textured graphite [PDF]

, 1982
A specially textured surface of pyrolytic graphite exhibits extremely low yields of secondary electrons and reduced numbers of reflected primary electrons after impingement of high energy primary electrons. An ion flux having an energy between 500 eV and
Curren, A. N., Forman, R., Sovey, J. S., Wintucky, E. G.   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Prioritizing Energy Performance Improvement Factors for Senior Centers Based on Building Energy Simulation and Economic Feasibility

Energies
This study examined energy performance improvement factors by analyzing both energy performance and the economic impacts to reduce energy costs for senior centers.
Arisae Nam, Young Il Kim
doaj   +1 more source

Sensitivity of cosmic-ray experiments to ultra-high-energy photons: reconstruction of the spectrum and limits on the superheavy dark matter

, 2009
We estimate the sensitivity of various experiments detecting ultra-high-energy cosmic rays to primary photons with energies above 10^19 eV. We demonstrate that the energy of a primary photon may be significantly (up to a factor of ~ 10) under- or ...
G. Gelmini, G. I. Rubtsov, L. D. Landau, M. I. Pravdin, N. Sakaki, O. E. Kalashev, S. Baker, S. V. Troitsky, S. V. Troitsky, T. Pierog, W. H. Press, Z. T. Zatsepin   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rev-Changes in Primary Energy Use and CO2 Emissions—An Impact Assessment for a Building with Focus on the Swedish Proposal for Nearly Zero Energy Buildings

Energies, 2017
In the European Union’s Energy Performance of Buildings Directive, the energy efficiency goal for buildings is set in terms of primary energy use.
Mattias Gustafsson, Richard Thygesen, Björn Karlsson, Louise Ödlund   +3 more
doaj   +1 more source