Results 91 to 100 of about 6,237,714 (303)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Mapping receptive fields in primary visual cortex

open access: yesThe Journal of Physiology, 2004
Nearly 40 years ago, in the pages of this journal, Hubel and Wiesel provided the first description of receptive fields in the primary visual cortex of higher mammals. They defined two classes of cortical cells, ‘simple’ and ‘complex’, based on neural responses to simple visual stimuli.
openaire   +3 more sources

Two-point Functions in Affine SL(N) Current Algebra

open access: yes, 1998
In this letter the explicit form of general two-point functions in affine SL(N) current algebra is provided for all representations, integrable or non-integrable.
Rasmussen, Jorgen
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Triploid Atlantic salmon (Salmo salar) may have increased risk of primary field outbreaks of infectious salmon anaemia. [PDF]

open access: yesJ Fish Dis, 2022
Aunsmo A   +7 more
europepmc   +1 more source

Conformal Invariance in Classical Field Theory

open access: yes, 1993
A geometric generalization of first-order Lagrangian formalism is used to analyse a conformal field theory for an arbitrary primary field. We require that global conformal transformations are Noetherian symmetries and we prove that the action functional ...
Grigore, D. R.
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Generators for primary closures of Galois fields

open access: yesFinite Fields and Their Applications, 2003
Let \(q\) be a prime power, \(k\) and \(e\) positive integers and \((\mathbb F_q,\mathbb F_{q^k},\mathbb F_{q^{ek}})\) a tower of finite fields of order \(q\), \(q^k\) and \(q^{ek}\), respectively. Let \({\mathcal F}\) denote the set of triples \((q,k,e)\) for which, for every \(a\in \mathbb F_{q^k}\) normal over \(\mathbb F_q\) (i.e.\ \(\{a,a^q,\dots ...
openaire   +1 more source

Mobilizing political support proved critical to a successful switch from tOPV to bOPV in Kano, Nigeria 2016

open access: yesBMC Public Health, 2018
Background Kano is one of the high-risk states for polio transmission in Northern Nigeria. The state reported more cases of wild polioviruses (WPVs) than any other state in the country.
Bashir Abba   +14 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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