Results 81 to 90 of about 33,684 (218)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Characteristics of medicinal plants in protected area “Dabeto” village Novi izvor (Bulgaria)

Растениевъдни науки, 2019
The present study examines the medicinal plants in the protected area PA "Dabeto", Novi izvor village in the region of Plovdiv. The received data is based on a three-year research of the flora in the protected zone.
Stoyan Georgiev, Koycho Koev, Teodora Barakova, Nikolay Kochev   +3 more
doaj  

Beyond viral load: Unravelling non-communicable disease patterns in Manicaland province, Zimbabwe

Journal of Public Health in Africa
Background: Non-communicable diseases (NCDs) among people living with human immunodeficient virus (HIV) are emerging and a leading cause of death in this population. Aim: To identify disease trends, prevalence and outcomes of NCDs among PLHIV. Setting: 
Kudzai F.V. Chokuona, Munyaradzi Mukuzunga, Tsitsi P. Juru, Addmore Chadambuka, Gerald Shambira, Notion T. Gombe, Mufuta Tshimanga   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Adolescent Girls and Young Women Initiative in Zimbabwe, 2018-2021: A secondary data analysis

Journal of Interventional Epidemiology and Public Health
Background: In Zimbabwe, the annual incidence of HIV among adolescent girls and young women (AGYW) is 9.5 times that of adolescent boys and young men. There is an AGYW initiative aimed at reducing new HIV infections among AGYW in Zimbabwe.
Godwin Choga, Owen Mugurungi, Tsitsi Patience Juru, Gibson Mandozana, Addmore Chadambuka, Notion Tafara Gombe, Gerald Shambira, Mufuta Tshimanga   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Human Immunodeficiency Virus Testing Trends Among Children in Kadoma City, Zimbabwe, 2015-2017

Journal of Interventional Epidemiology and Public Health
Introduction: Zambia is a cholera-endemic country and the epidemic in the capital, Lusaka, 2017-2018, caused more than 5,900 cases and 110 deaths. Low-income resident districts in Lusaka are known as hotspots for cholera outbreaks.
Chamunorwa Mhembe, Daniel Chirundu, Notion Tafara Gombe, Tsitsi Patience Juru, Addmore Chadambuka, Gerald Shambira, Simbarashe Chiwanda, Mufuta Tshimanga   +7 more
doaj   +1 more source

Theorization of New Practices in Emerging Organizational Fields

Vikalpa, 2017
Executive Summary Organizational actions are subject to multiple interpretations by the constituents of organizational field and are often prone to lose legitimacy in an uncertain environment.
Sushanta Kumar Sarma
doaj   +1 more source

Primary Decomposition of Modules: Two Variables over a Field

Journal of Symbolic Computation, 1993
Let \(k\) be a field. Let \(N\) be a submodule of the free \(k[x,y]\)-module \(k[x,y]^ s\) for some \(s>0\). First, the author gives a partial structure theorem for Gröbner bases of \(N\). Secondly, she presents an algorithm for computing the primary decomposition of \(N\subset k[x,y]^ s\).
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source