Results 81 to 90 of about 13,926,876 (298)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Primary visual cortex neurons that contribute to resolve the aperture problem [PDF]

, 2006
It is traditional to believe that neurons in primary visual cortex are sensitive only or principally to stimulation within a spatially restricted receptive field (classical receptive field).
M. Pulgarin, M.P. Young, Nevado, Angel, K. Guo, Robertson, Robert, R. Robertson, S. Mahmoodi, Mahmoodi, Sasan, Pulgarin, M, Guo, Kun, A. Nevado, Young, Malcom   +11 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Primary Field Cybernetics

Primary Field Cybernetics: From Spectral-Phase Flow to a Symformic Theory of Control This article develops Primary Field Cybernetics (PFC) as a cybernetic theory derived from the ontology of Symformism and the field architecture of Dynamical Informational Field Theory (DIFT).
openaire   +1 more source

Mapping receptive fields in primary visual cortex

The Journal of Physiology, 2004
Nearly 40 years ago, in the pages of this journal, Hubel and Wiesel provided the first description of receptive fields in the primary visual cortex of higher mammals. They defined two classes of cortical cells, ‘simple’ and ‘complex’, based on neural responses to simple visual stimuli.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Enhancing surveillance for dengue fever in Oyo State, Nigeria – a one health approach

One Health Outlook
Background Dengue fever (DF) poses a growing global threat, necessitating a comprehensive one-health approach to address its complex interplay between human, animal, and environmental factors.
Olawale Sunday Animasaun, Joseph Ojonugwa Shaibu, Busayo Kayode Akomolafe, Olamide Priscilla Animasaun, Piring’ar Mercy Niyang, Olukemi Titilope Olugbade, Akinfemi Oyewumi Akinyode, Ibukun Akinsola Omisakin, Adedapo Olufemi Adeogun, Rosemary Ajuma Audu   +9 more
doaj   +1 more source

An in-silico comparative cross-sectional diagnostic- accuracy study evaluating artificial intelligence platforms in identifying autism spectrum disorder from standardized pediatric case vignettes 2026

Frontiers in Psychiatry
Background and objectiveThis study evaluates the capability of various general-purpose and healthcare-specialized Artificial Intelligence (AI) platforms in identifying Autism Spectrum Disorder (ASD) from clinical narratives.MethodsUsing twenty ...
Suhail H. Serbaya, Saud Hasan Surbaya, Tamara Abdulrahman Hafiz, Mohammad Fouad Mohammad Khatib Sambas, Khalid Mohammed Saeed Alshahrani   +4 more
doaj   +1 more source

Primary units in cyclotomic fields

, 2009
We investigate the interrelationships of three notions of primary units in the local cyclotomic field of $p$-th roots of~1($p$ being an odd prime number), especially with reference to global units.
openaire   +2 more sources