Results 91 to 100 of about 33,684 (218)

Children who have received no routine polio vaccines in Nigeria: Who are they and where do they live?

Human Vaccines & Immunotherapeutics, 2017
Nigeria has made remarkable progress against polio, but 2 wild polio virus cases were reported in August 2016; putting an end to 2 y without reported cases.
Olalekan A. Uthman, Sulaimon T. Adedokun, Tawa Olukade, Samuel Watson, Olatunji Adetokunboh, Adeyinka Adeniran, Solomon A. Oyetoyan, Saheed Gidado, Stephen Lawoko, Charles S. Wiysonge   +9 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network

Frontiers in Immunology
BackgroundAdults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected.
Meredith Leston, Debasish Kar, Anna Forbes, Gavin Jamie, Rashmi Wimalaratna, Gunjan Jiwani, José M. Ordóñez-Mena, Daniel E. Stewart, Daniel E. Stewart, Heather Whitaker, Mark Joy, Lennard Y. W. Lee, F. D. Richard Hobbs, Simon de Lusignan   +13 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Determinants of COVID-19 vaccine acceptance among residents of Ilorin metropolis, Nigeria, 2023: A community-based cluster survey

Journal of Interventional Epidemiology and Public Health
Introduction: At least 70% of the eligible population in Nigeria must be vaccinated for the country to achieve herd immunity against COVID-19. Suboptimal vaccine acceptance could delay the timely achievement of this objective.
Abiodun Ebenezer Kolapo, Olufunmilayo Ibitola Fawole, Joshua Odunayo Akinyemi, Magbagbeola David Dairo, Muhammad Shakir Balogun   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Estimating the crop coefficient of meadow ecosystems and its driving factors using machine learning on the Qinghai–Tibet Plateau

Journal of Hydrology: Regional Studies
Study region: Qinghai–Tibet Plateau (QTP), China Study focus: This study aims to improve crop coefficient (Kc) estimation for alpine meadows on the Qinghai–Tibet Plateau, where data scarcity and complex climate conditions make evapotranspiration (ET ...
Zhiming Xia, Bin Wang, Liping Guo, Xiaowei Guo   +3 more
doaj   +1 more source

[Primary care: A definition of the field to develop research].

Revue d'epidemiologie et de sante publique, 2018
Research in the field of primary care has dramatically increased in France in recent years, especially since 2013 with the introduction of primary care as a thematic priority for research proposals launched by the Ministry of Health (Direction générale de l'offre de soins).The RECaP (Research in Clinical Epidemiology and Public Health) network is a ...
Afonso, Mélanie, Bénard, Antoine, Chapron, Anthony, Chau, Kenora, Doussiet, Eric, Guillemin, Francis, Guillo, Sylvie, Gonthier, Damien, Lafarge, Sophie, Lapeyre-Mestre, Mestre, Oriol, Mathieu, Tubach, Florence, Verga-Gérard, A.   +12 more
openaire   +2 more sources