Results 91 to 100 of about 13,926,876 (298)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Parkside Primary School PTA letter

open access: yes, 1996
Letter to parents of a resolution taken at a meeting of the Parkside Primary School PTA, held at the Muslim Movement Hall, to oppose the department's envisaged rationalisation ...
Parent Teacher Assocation, Parkside Primary School
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Characteristics of medicinal plants in protected area “Dabeto” village Novi izvor (Bulgaria)

open access: yesРастениевъдни науки, 2019
The present study examines the medicinal plants in the protected area PA "Dabeto", Novi izvor village in the region of Plovdiv. The received data is based on a three-year research of the flora in the protected zone.
Stoyan Georgiev   +3 more
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Review of Queensland's Primary Production Food Safety Legislation: Discussion Paper [PDF]

open access: yes
A review of the Food Production (Safety) Act 2000 and the current regulatory framework governing primary production is timely. This review supports the government’s ambitious target to boost primary production output to $30 billion by 2030.
Department of Primary Industries, Queensland
core   +2 more sources

COVID-19 outbreak investigation among construction workers at a construction site in Harare, Zimbabwe February - March 2021 Amanda Sarah Thakataka, Joseph

open access: yesJournal of Interventional Epidemiology and Public Health
Introduction: On February 16, 2021, a construction site in Harare recorded 26 COVID-19 cases during routine worker screening. Over five days, the positivity rate increased from 4.14 to 7.29%. Workplace outbreaks affect productivity.
Amanda Sarah Thakataka   +5 more
doaj   +1 more source

Mobilizing political support proved critical to a successful switch from tOPV to bOPV in Kano, Nigeria 2016

open access: yesBMC Public Health, 2018
Background Kano is one of the high-risk states for polio transmission in Northern Nigeria. The state reported more cases of wild polioviruses (WPVs) than any other state in the country.
Bashir Abba   +14 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Field study on thermal comfort in a UK primary school

open access: yes
This paper presents findings from a field survey in a naturally ventilated primary school building in Southampton, UK. The study included thermal comfort surveys and simultaneous measurements of indoor environmental variables.
James, P.A.B.   +3 more
core   +1 more source

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