Results 61 to 70 of about 13,926,876 (298)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Knowledge, risk perception and uptake of COVID-19 vaccination among internally displaced persons in complex humanitarian emergency setting, Northeast Nigeria

BMC Public Health
Background Owing to crowded and unsanitary conditions, internally displaced persons (IDPs) have an increased risk of COVID-19 infection. Adoption of COVID-19 preventive measures among this population is premised on accurate information, adequate ...
Saheed Gidado, Melton Musa, Ahmed Ibrahim Ba’aba, Mark Rohit Francis, Lilian Akudo Okeke, Fatima Lawan Bukar, Patrick M. Nguku, Idris Suleman Hadejia, Isa Ali Hassan, Ibrahim Muhammad Bande, Martins Onuoha, Rabi Usman, Gideon Ugbenyo, Ntadom Godwin, Elsie Ilori, Aisha Aliyu Abulfathi, Lawi Auta Mshelia, Abede Momoh Mohammed, Muhammad Maijawa Abdullahi, Mohammed Isa Bammami, Pekka Nuorti, Salla Atkins   +21 more
doaj   +1 more source

Improving timeliness of routine primary healthcare data: Healthcare workers’ perspectives on a prompt-enabled responsive feedback mechanism in Northern Nigeria, 2022

Journal of Interventional Epidemiology and Public Health
Introduction: Poor data quality from health facilities in Nigeria remains a significant barrier to effective decision-making. One identified contributor is the delay in documenting data at the point of service.
Clara Oguji, Ugochukwu Osigwe, Adam Attahiru, Mariam Ogo, Lawal Sani Muhammad, Amal Oladimeji, Adefisoye Adewole, Aliyu Nurudeen, David Nyampa Barau, Gabriel Adah, Alex Ash, Yusuf Yusufari, Masduk Abdukarim, Ndadilnasiya Endie Waziri, Patrick Nguku   +14 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis [PDF]

CHAID; Decision tree; Diabetes; MACECHAID; Árbol de decisión; Diabetes; MACECHAID; Decision tree; Diabetes; MACECardiovascular disease is the leading cause of mortality among individuals with Type 2 Diabetes Mellitus (T2DM). This study developed a simple
Vila-Corcoles, Angel, de diego cabanes, cinta, Ribas Seguí, Domingo J, Forcadell, Mª José, Ochoa-Gondar, Olga, SATUÉ-GRACIA, Eva, Martín Luján, Francisco M   +6 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Prevalence and Risk Factors of Elevated Blood Lead in Children in Gold Ore Processing Communities, Zamfara, Nigeria, 2012

Journal of Health and Pollution, 2016
Background. In March 2010, Medecins Sans Frontieres/Doctors Without Borders detected an outbreak of acute lead poisoning in Zamfara State, northwestern Nigeria, linked to low-technology gold ore processing.
John A. Kaufman, Mary Jean Brown, Nasir T. Umar-Tsafe, Muhammad Bashir Adbullahi, Kabiru I. Getso, Ibrahim M. Kaita, Binta Bako Sule, Ahmed Ba'aba, Lora Davis, Patrick M. Nguku, Nasir Sani-Gwarzo   +10 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source