Results 51 to 60 of about 13,926,876 (298)

Neural Field Model of Receptive Field Restructuring in Primary Visual Cortex

Neural Computation, 2001
Receptive fields (RF) in the visual cortex can change their size depending on the state of the individual. This reflects a changing visual resolution according to different demands on information processing during drowsiness. So far, however, the possible mechanisms that underlie these size changes have not been tested rigorously.
Suder, Katrin, Wennekers, Thomas, Wörgötter, Florentin   +2 more
openaire   +4 more sources

Primary singularities of vector fields on surfaces [PDF]

Geometriae Dedicata, 2019
Unless another thing is stated one works in the $C^\infty$ category and manifolds have empty boundary. Let $X$ and $Y$ be vector fields on a manifold $M$. We say that $Y$ tracks $X$ if $[Y,X]=fX$ for some continuous function $f\colon M\rightarrow\mathbb R$.
Hirsch, MW, Turiel, FJ
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tuberculosis Notification Surveillance System Evaluation in Bulilima District Zimbabwe, 2020

Journal of Interventional Epidemiology and Public Health
Introduction: The World Health Organisation (WHO) recommends the detection of 90% of WHO's estimated TB incidence. In 2020 Bulilima District detected 31% of Zimbabwe`s estimated incidence thereby failing to meet the WHO detection target.
Mutizwa Thomas Mupedziswa, Rudo Chikodzore, Addmore Chadambuka, Tsitsi Patience Juru, Mujinga Karakadzai, Notion Tafara Gombe, Chukwuma David Umeokonkwo, Mufuta Tshimanga   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evaluation of Surveillance System for Adverse Drug Reaction Due to Antiretroviral Drugs, Mazowe District, Zimbabwe, 2021

Journal of Interventional Epidemiology and Public Health
Introduction: Antiretroviral drugs (ARVs) are associated with the occurrence of adverse drug reactions (ADRs). The Medicines Control Authority of Zimbabwe requires that all ADRs be reported within 15 days of detection.
Godwin Choga, Owen Mugurungi, Tsitsi Patience Juru, Addmore Chadambuka, Notion Tafara Gombe, Gerald Shambira, Chukwuma David Umeokonkwo, Mufuta Tshimanga   +7 more
doaj   +1 more source