Results 51 to 60 of about 33,684 (218)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Evaluation of Surveillance System for Adverse Drug Reaction Due to Antiretroviral Drugs, Mazowe District, Zimbabwe, 2021

Journal of Interventional Epidemiology and Public Health
Introduction: Antiretroviral drugs (ARVs) are associated with the occurrence of adverse drug reactions (ADRs). The Medicines Control Authority of Zimbabwe requires that all ADRs be reported within 15 days of detection.
Godwin Choga, Owen Mugurungi, Tsitsi Patience Juru, Addmore Chadambuka, Notion Tafara Gombe, Gerald Shambira, Chukwuma David Umeokonkwo, Mufuta Tshimanga   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Knowledge, risk perception and uptake of COVID-19 vaccination among internally displaced persons in complex humanitarian emergency setting, Northeast Nigeria

BMC Public Health
Background Owing to crowded and unsanitary conditions, internally displaced persons (IDPs) have an increased risk of COVID-19 infection. Adoption of COVID-19 preventive measures among this population is premised on accurate information, adequate ...
Saheed Gidado, Melton Musa, Ahmed Ibrahim Ba’aba, Mark Rohit Francis, Lilian Akudo Okeke, Fatima Lawan Bukar, Patrick M. Nguku, Idris Suleman Hadejia, Isa Ali Hassan, Ibrahim Muhammad Bande, Martins Onuoha, Rabi Usman, Gideon Ugbenyo, Ntadom Godwin, Elsie Ilori, Aisha Aliyu Abulfathi, Lawi Auta Mshelia, Abede Momoh Mohammed, Muhammad Maijawa Abdullahi, Mohammed Isa Bammami, Pekka Nuorti, Salla Atkins   +21 more
doaj   +1 more source

Improving timeliness of routine primary healthcare data: Healthcare workers’ perspectives on a prompt-enabled responsive feedback mechanism in Northern Nigeria, 2022

Journal of Interventional Epidemiology and Public Health
Introduction: Poor data quality from health facilities in Nigeria remains a significant barrier to effective decision-making. One identified contributor is the delay in documenting data at the point of service.
Clara Oguji, Ugochukwu Osigwe, Adam Attahiru, Mariam Ogo, Lawal Sani Muhammad, Amal Oladimeji, Adefisoye Adewole, Aliyu Nurudeen, David Nyampa Barau, Gabriel Adah, Alex Ash, Yusuf Yusufari, Masduk Abdukarim, Ndadilnasiya Endie Waziri, Patrick Nguku   +14 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prevalence and Risk Factors of Elevated Blood Lead in Children in Gold Ore Processing Communities, Zamfara, Nigeria, 2012

Journal of Health and Pollution, 2016
Background. In March 2010, Medecins Sans Frontieres/Doctors Without Borders detected an outbreak of acute lead poisoning in Zamfara State, northwestern Nigeria, linked to low-technology gold ore processing.
John A. Kaufman, Mary Jean Brown, Nasir T. Umar-Tsafe, Muhammad Bashir Adbullahi, Kabiru I. Getso, Ibrahim M. Kaita, Binta Bako Sule, Ahmed Ba'aba, Lora Davis, Patrick M. Nguku, Nasir Sani-Gwarzo   +10 more
doaj   +1 more source