Results 211 to 220 of about 2,834,721 (313)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Primary intestinal lymphangiectasia – A rare cause of growth delay

Pediatrics and Neonatology
Inês Pais-Cunha, Cátia Silva, Laura Leite de Almeida, Rita Calejo, Carla Vasconcelos, Céu Espinheira, Isabel Pinto Pais, Eunice Trindade   +7 more
doaj   +1 more source

Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model. [PDF]

BMC Med
Stögbauer F, Weiser T, Dezfouli AB, Wirth J, Engelmann L, Budczies J, Ourailidis I, Boxberg M, Pigorsch K, Schmidl B, Strittmatter N, Steiger K, Mogler C, Wollenberg B.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Glycemia Range and Offspring Weight and adiposity in response To Human milk (GROWTH) study: protocol for an observational cohort designed to study lactational programming. [PDF]

BMJ Open
Josefson JL, Gregg B, Sen S, Rajakumar K, McGowan EC, Andrei AC, Arend AB, Rick AM, Marshall E, Caal K, Robinson DT.   +10 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Screening of Plant Growth Regulators for Promoting Rooting of Pitaya Cuttings. [PDF]

Plants (Basel)
Zhong C, Zheng C, Wang M, Sheng J, Wang Y, Huang J, Tang H, Chen Y.   +7 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Influence of financial toxicity on posttraumatic growth in primary caregivers of cancer patients undergoing chemotherapy: the chain mediating effect of benefit finding and self-disclosure. [PDF]

BMC Nurs
Ren X, Gong X, Zhang X, Zhang J, Lin J, Cai Y, Song W, Zhang Q, Gao S, Lin S, Ji L, Li M.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source