Results 221 to 230 of about 2,834,721 (313)

Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer. [PDF]

Bone Res
Wu J, Deng M, Ye F, Deng W, Wu Z, Zheng X, Song C, Zou Y, Tang H.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Metachronous Primary Pancreatic Neuroendocrine Tumor and Adenocarcinoma: A Case Report. [PDF]

Cancer Rep (Hoboken)
Fatyanova AS, Kalinina ME, Islamova DF, Shchekoturov IO, Lerner JV, Stashevskaya NA, Burko P, Miltiadis I.   +7 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease. [PDF]

J Cachexia Sarcopenia Muscle
Nicholson T, Allen SL, Quinlan JI, Dhaliwal A, Macleod M, Price J, Hazeldine J, Sagmeister MS, Ditchfield C, McGee KC, Williams FR, Elsharkawy AM, Armstrong MJ, Greig CA, Lord JM, Breen L, Jones SW.   +16 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Time-Varying Hormonal Treatment and Metastasis-Free Survival Among ER+ Breast Cancer Patients: A Natural History Modelling Approach. [PDF]

Stat Med
Orsini L, Gasparini A, Czene K, Humphreys K.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Early Neurological Improvement and Ambulation Recovery After Delayed Surgery in Surgically Selected Nonambulatory Metastatic Epidural Spinal Cord Compression: A Retrospective Cohort Study. [PDF]

Curr Oncol
Baydar AT, Taskala B, Topal B, Bayindir M, Batman YE, Yilmaz I, Dalgic A.   +6 more
europepmc   +1 more source