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Experimental and Clinical Endocrinology and Diabetes, 2002
Primary hyperaldosteronism (PHA) is regarded as a rare disease with prevalence rates of 0.5 to 2% within the hypertensive population. Recent studies using more detailed screening procedures in small hypertensive cohorts have suggested that PHA may be more common than previously thought (3-18%).
S Diederich
exaly +5 more sources
Primary hyperaldosteronism (PHA) is regarded as a rare disease with prevalence rates of 0.5 to 2% within the hypertensive population. Recent studies using more detailed screening procedures in small hypertensive cohorts have suggested that PHA may be more common than previously thought (3-18%).
S Diederich
exaly +5 more sources
Diagnosis of primary hyperaldosteronism
Medicina Clínica (English Edition), 2022Primary aldosteronism (PA) is the most common cause of secondary arterial hypertension. Moreover, it is associated with a higher cardio-metabolic risk than the observed in patients with essential arterial hypertension (EHT). Therefore, a high index of clinical suspicion for PA is mandatory.
Marta, Araujo-Castro +1 more
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Medical Clinics of North America, 1988
Primary hyperaldosteronism is a challenging diagnosis because of its low incidence and variable pathophysiology. Serum potassium, properly done, is the routine screening test, but is not without its limitations. Confirmation of the diagnosis requires demonstration of abnormally high and nonsuppressible values for aldosterone in plasma and urine and low
R H, Noth, E G, Biglieri
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Primary hyperaldosteronism is a challenging diagnosis because of its low incidence and variable pathophysiology. Serum potassium, properly done, is the routine screening test, but is not without its limitations. Confirmation of the diagnosis requires demonstration of abnormally high and nonsuppressible values for aldosterone in plasma and urine and low
R H, Noth, E G, Biglieri
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Endocrine Practice, 1997
To characterize the syndrome of primary aldosteronism and summarize diagnostic and therapeutic strategies.We review the mechanisms of action of aldosterone and outline features that distinguish the major subtypes of aldosteronism.The state of aldosterone excess should be suspected in every patient manifesting hypertension and hypokalemia.
M T, Laurel, U M, Kabadi
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To characterize the syndrome of primary aldosteronism and summarize diagnostic and therapeutic strategies.We review the mechanisms of action of aldosterone and outline features that distinguish the major subtypes of aldosteronism.The state of aldosterone excess should be suspected in every patient manifesting hypertension and hypokalemia.
M T, Laurel, U M, Kabadi
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Primary hyperaldosteronism in pregnancy
American Journal of Obstetrics and Gynecology, 1986A case is reported of a primigravid woman presenting in midgestation with severe hypertension caused by primary hyperaldosteronism. Symptomatic treatment with an aldosterone blocker, a peripheral vasodilator, and a combined alpha beta-blocker allowed pregnancy to continue to 36 weeks' gestation.
F K, Lotgering +2 more
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THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISM
The Lancet, 1981An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension.
N J, Vaughan +6 more
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Primary Hyperaldosteronism in Pregnancy
Australian and New Zealand Journal of Medicine, 1982We report a case of primary hyperaldosteronism in a 37-year-old woman presenting early in pregnancy with hypertension and hypokalaemia. Plasma renin concentration was suppressed and unaffected by sodium restriction or upright posture at 16 and 35 weeks gestation, or seven days post-partum.
T G, Hammond +4 more
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Amiloride in primary hyperaldosteronism
Clinical Pharmacology and Therapeutics, 1982Amiloride is a potassium-sparing diuretic used in spontaneous and diuretic-induced hypokalemia. The effect of amiloride was studied prospectively in 12 patients with primary hyperaldosteronism. Four patients had unilateral adrenal adenomas and eight had bilateral adrenal hyperplasia. All patients were hypertensive and their mean plasma potassium levels
G T, Griffing +5 more
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Radiology in primary hyperaldosteronism
American Journal of Roentgenology, 1976Autonomous hypersecretion of aldosterone (primary hyperaldosteronism) is caused by either hyperplasia (usually bilateral) or an adenoma (frequently unilateral) of the adrenal cortex. Systemic hypertension due to an aldosteronoma is a potentially curable condition through surgical extirpation of the offending organ.
H Y, Yune +6 more
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Treatment of primary hyperaldosteronism
Medicina Clínica (English Edition), 2020Primary aldosteronism is associated with higher cardiovascular and renal morbidity and mortality than essential hypertension in age- and sex-matched patients with the same degree of blood pressure elevation. Therefore, it is essential to establish a specific treatment to avoid the deleterious effects of aldosterone excess.
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