Results 101 to 110 of about 21,130 (289)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Autoimmune manifestations in primary immunodeficiencies

Современная ревматология
According to current understanding of the mechanisms underlying primary immunodeficiencies (PIDs) and their clinical course, there is a clear and clinically significant association between this group of disorders and autoimmune manifestations (AIMs).This
M. I. Kaleda, I. P. Nikishina
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Novel Aspects in Immunodeficiencies

, 2009
This thesis reports the results I obtained during my PhD course in “Human Reproduction, Development and Growth” (XXII Cycle) from 2006 to 2009. The field of the clinical description, genetic characterization, and immunological investigation of novel ...
Amorosi, Stefania
core  

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Improving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation sequencing

, 2020
International audienceImproving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation ...
Hanein, Sylvain, Mahlaoui, Nizar, Chevalier, Samuel, Castelle, Martin, Pasquet, Marlène, Diana, Jean-Sébastien, Latour, Sylvain, Moshous, Despina, Bader-Meunier, Brigitte, Comont, Thibault, Renaud, Nicholas, Hermine, Olivier, Boutboul, David, Rosain, Jérémie, Suarez, Felipe, Fischer, Alain, de Saint Basile, Geneviève, Gil, Marine, Béziat, Vivien, Galicier, Lionel, Barlogis, Vincent, Neven, Bénédicte, Oksenhendler, Eric, Bustamante, Jacinta, Merlin, Etienne, Kracker, Sven, Lambert, Nathalie, Chahla, Wadih Abou, de Villartay, Jean-Pierre, Rieux-Laucat, Frédéric, André, Isabelle, Fourrage, Cécile, Malphettes, Marion, Fieschi, Claire, Lefèvre-Utile, Alain, Nitschke, Patrick, Grandin, Virginie, Lagresle-Peyrou, Chantal, Fusaro, Mathieu, Picard, Capucine, Vogt, Guillaume, Blanche, Stéphane, Bole, Christine, Hulier-Ammar, Elisabeth, Alcais, Alexandre   +44 more
core   +1 more source

Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells

Frontiers in Immunology, 2019
Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and recurrent infections that require lifelong immunoglobulin replacement and prophylactic antibiotic treatment. Disease incidence is estimated to be 1:25,000 worldwide,
Emily S. J. Edwards, Emily S. J. Edwards, Julian J. Bosco, Julian J. Bosco, Pei M. Aui, Pei M. Aui, Robert G. Stirling, Robert G. Stirling, Paul U. Cameron, Paul U. Cameron, Josh Chatelier, Josh Chatelier, Fiona Hore-Lacy, Fiona Hore-Lacy, Robyn E. O'Hehir, Robyn E. O'Hehir, Robyn E. O'Hehir, Menno C. van Zelm, Menno C. van Zelm, Menno C. van Zelm   +19 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source