Results 71 to 80 of about 30,146 (197)

What is the burden of immunoglobulin replacement therapy in adult patients with primary immunodeficiencies? A systematic review [PDF]

, 2018
© 2018 Jones, Vogt, Chambers, Clowes and Shrimpton. Background: Primary immunodeficiency disorders (PIDs) are a group of heterogeneous rare disorders, whereby the immune system is missing or not functioning adequately.
Ballow, Beaute, Berger, Bienvenu, Borte, Chapel, Chapel, Daly, Dash, Espanol, Eton, Gardulf, Gardulf, Gardulf, Gardulf, Gardulf, Gardulf, Gardulf, Hansen, Heath, Howard, Jiang, Jones, Kittner, Misbah, Mohamed, Mozaffari, Nicolay, Picard, PID, Quinti, Quinti, Rider, Routes, Sav, Skoda-Smith, Sorensen, Tabolli, Tcheurekdjian, Vultaggio, Wood   +40 more
core   +4 more sources

Primary immunodeficiencies and B-cell lymphomas

Boletín Médico del Hospital Infantil de México, 2016
Introduction: In primary immunodeficiencies there is a failure in the anti-tumor defense. Common variable immunodeficiency (CVID) is one of the most common primary immunodeficiencies characterized by an alteration in the differentiation of B lymphocytes (
María Anunciación Martín-Mateos, Mónica Piquer Gibert   +1 more
doaj   +1 more source

Protective immunity against Trypanosoma cruzi [PDF]

, 2009
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel, Padilla, Ángel Marcelo, Parodi Ramoneda, Cecilia María   +2 more
core   +1 more source

Mutations in topoisomerase IIβ result in a B cell immunodeficiency. [PDF]

, 2019
B cell development is a highly regulated process involving multiple differentiation steps, yet many details regarding this pathway remain unknown. Sequencing of patients with B cell-restricted immunodeficiency reveals autosomal dominant mutations in ...
Austin, Caroline A, Booshehri, Laela M, Broderick, Lori, Brydges, Susannah D, Cowell, Ian G, Croker, Ben A, Frazer, Kelly A, Gebauer, Corinna, Guaderrama, Marisela, Hakonarson, Hakon, Harr, Margaret, Hoffman, Hal M, Hügle, Boris, Kucharova, Karolina, Li, Dong, McGeough, Matthew D, Patel, Niraj C, Putnam, Christopher D, Wang, Jian, Xu, Xun, Yost, Shawn, Zackai, Elaine, Zhang, Jianguo   +22 more
core  

Consanguinity and polygenic diseases: a model for antibody deficiencies [PDF]

, 2014
Primary immunodeficiencies represent a heterogeneous group of disorders of the immune system, predisposing to various types of infections. Among them, common variable immunodeficiency is the most common symptomatic antibody deficiency.
Angelino, G, Cancrini, C, Di Pierro, V, Ferrari, S, Finocchi, A, Rossi, P, Zuntini, R   +6 more
core   +2 more sources

Current Approach to Primary Immunodeficiency Diseases

Southern Clinics of Istanbul Eurasia, 2019
Primary immunodeficiency diseases (PIDD) are inherited disorders resulting from defects in diverse elements of the human immune system. Currently, more than 330 PIDDs have been described, and the molecular (genetic) bases for more than 320 of them are ...
Öner Özdemir
doaj   +1 more source

Actinomycosis may be presented in unusual organs: A report of two cases [PDF]

, 2009
Actinomycosis is a chronic granulomatous suppurative disease characterized by direct extension to the contagious tissue with the formation of multiple drainage sinus tracts through which tiny colonies of organisms called sulfur granules are discharged ...
Golsha, R., Mortazavi, B., Najafi, L., Rezaei-Shirazi, R., Roshandel, G., Vakilinejhad, M.   +5 more
core  

Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells

Frontiers in Immunology, 2019
Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and recurrent infections that require lifelong immunoglobulin replacement and prophylactic antibiotic treatment. Disease incidence is estimated to be 1:25,000 worldwide,
Emily S. J. Edwards, Emily S. J. Edwards, Julian J. Bosco, Julian J. Bosco, Pei M. Aui, Pei M. Aui, Robert G. Stirling, Robert G. Stirling, Paul U. Cameron, Paul U. Cameron, Josh Chatelier, Josh Chatelier, Fiona Hore-Lacy, Fiona Hore-Lacy, Robyn E. O'Hehir, Robyn E. O'Hehir, Robyn E. O'Hehir, Menno C. van Zelm, Menno C. van Zelm, Menno C. van Zelm   +19 more
doaj   +1 more source

Impaired STAT3-Dependent Upregulation of IL2Rα in B Cells of a Patient With a STAT1 Gain-of-Function Mutation

Frontiers in Immunology, 2019
Heterozygous STAT1 gain-of-function (GOF) mutations form the most common genetic cause of chronic mucocutaneous candidiasis (CMC). In such patients, increased STAT1 function leads to impaired STAT3-dependent activation of IL-17A and IL-17F in T cells ...
Menno C. van Zelm, Menno C. van Zelm, Menno C. van Zelm, Julian J. Bosco, Julian J. Bosco, Pei M. Aui, Pei M. Aui, Samuel De Jong, Samuel De Jong, Fiona Hore-Lacy, Fiona Hore-Lacy, Robyn E. O'Hehir, Robyn E. O'Hehir, Robert G. Stirling, Robert G. Stirling, Paul U. Cameron, Paul U. Cameron, Paul U. Cameron   +17 more
doaj   +1 more source

Autoimmune manifestations in primary immunodeficiencies

Современная ревматология
According to current understanding of the mechanisms underlying primary immunodeficiencies (PIDs) and their clinical course, there is a clear and clinically significant association between this group of disorders and autoimmune manifestations (AIMs).This
M. I. Kaleda, I. P. Nikishina
doaj   +1 more source