Results 61 to 70 of about 21,130 (289)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Gene therapy of primary T cell immunodeficiencies.

, 2013
International audienceGene therapy of severe combined immunodeficiencies has been proven to be effective to provide sustained correction of the T cell immunodeficiencies.
Cavazzana-Calvo, Marina, Fischer, Alain, Hacein-Bey-Abina, Salima   +2 more
core   +1 more source

Genetic basis of primary immunodeficiencies. Combined immunodeficiencies (review)

Каразінський імунологічний журнал
Background. Primary immunodeficiencies are a large and heterogeneous group of hereditary disorders characterized by disorders in the development, functioning or regulation of the immune system.
L.V. Bieliaieva, K.V. Vovk, L.L. Sherstiuk, O.O. Vlasenko   +3 more
doaj   +1 more source

Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases?

Frontiers in Immunology, 2021
Autoimmune diseases recognize a multifactorial pathogenesis, although the exact mechanism responsible for their onset remains to be fully elucidated.
Elena Gianchecchi, Elena Gianchecchi, Domenico V. Delfino, Alessandra Fierabracci   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Primary immunodeficiency for the primary care provider [PDF]

Paediatrics & Child Health, 2016
Primary immunodeficiencies are a group of heterogeneous disorders resulting from defects affecting the function of ≥1 parts of the immune system. Current estimates of the prevalence of primary immunodeficiency disease are one in 1200 patients. In Ontario, where the average general practitioner follows 1300 to 2000 patients, an estimated two patients ...
A W, O'Keefe, M, Halbrich, M, Ben-Shoshan, C, McCusker   +3 more
openaire   +3 more sources

Dysfunctional Immune Synapses in T Cell Immunodeficiencies

, 2021
Adaptive immune responses take place in the T cell area of secondary lymphoid organs, where, on encounter of antigen-presenting cells (APCs) bearing specific MHC-associated antigen, T lymphocytes assemble a highly organized intercellular junction ...
Patrussi, L., Laura Patrussi, Cosima Tatiana Baldari, D'Elios, M. M., Mario Milco D’Elios, Capitani, N., Baldari, C. T., Nagaja Capitani   +7 more
core   +1 more source

Registry of primary immunodeficiencies in children at a fourth level hospital. Bogota, 2010-2016

Revista Alergia México, 2018
Background: Primary immunodeficiencies are inherited diseases that compromise numerous systems and whose clinical manifestation is varied. It is an underdiagnosed pathology in Colombia.
Ángela Pedraza, María Isabel Vargas-Rumilla, Juan Leandro Ramírez-Roa   +2 more
doaj   +1 more source

Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source