Results 61 to 70 of about 4,304,560 (276)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Genetic basis of primary immunodeficiencies. Combined immunodeficiencies (review)

Каразінський імунологічний журнал
Background. Primary immunodeficiencies are a large and heterogeneous group of hereditary disorders characterized by disorders in the development, functioning or regulation of the immune system.
L.V. Bieliaieva, K.V. Vovk, L.L. Sherstiuk, O.O. Vlasenko   +3 more
doaj   +1 more source

IDR knowledge base for primary immunodeficiencies [PDF]

, 2007
Background The ImmunoDeficiency Resource (IDR) is a knowledge base for the integration of the clinical, biochemical, genetic, genomic, proteomic, structural, and computational data of primary immunodeficiencies. The need for the IDR arises from the lack
Väliaho, Jouni, Samarghitean, Crina, Crina Samarghitean, Vihinen, Mauno, Jouni Väliaho, Mauno Vihinen   +5 more
core   +1 more source

Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases?

Frontiers in Immunology, 2021
Autoimmune diseases recognize a multifactorial pathogenesis, although the exact mechanism responsible for their onset remains to be fully elucidated.
Elena Gianchecchi, Elena Gianchecchi, Domenico V. Delfino, Alessandra Fierabracci   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

Frontiers in Immunology, 2014
We report the updated classification of primary immunodeficiencies compiled by the Expert Committee of the International Union of Immunological Societies.
Waleed eAl-Herz, Waleed eAl-Herz, Aziz eBousfiha, Jean-Laurent eCasanova, Jean-Laurent eCasanova, Talal eChatila, Talal eChatila, Mary Ellen eConley, Charlotte eCunningham-Rundles, Amos eEtzioni, Jose Luis Franco, Hubert Bobby Gaspar, Steven eHolland, Christoph eKlein, Shigeaki eNonoyama, Hans eOchs, Eric eOksenhendler, Capucine ePicard, Capucine ePicard, Jennifer ePuck, Kathleen eSullivan, Mimi eTang, Mimi eTang   +22 more
doaj   +1 more source

Primary immunodeficiency for the primary care provider [PDF]

Paediatrics & Child Health, 2016
Primary immunodeficiencies are a group of heterogeneous disorders resulting from defects affecting the function of ≥1 parts of the immune system. Current estimates of the prevalence of primary immunodeficiency disease are one in 1200 patients. In Ontario, where the average general practitioner follows 1300 to 2000 patients, an estimated two patients ...
A W, O'Keefe, M, Halbrich, M, Ben-Shoshan, C, McCusker   +3 more
openaire   +3 more sources

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Registry of primary immunodeficiencies in children at a fourth level hospital. Bogota, 2010-2016

Revista Alergia México, 2018
Background: Primary immunodeficiencies are inherited diseases that compromise numerous systems and whose clinical manifestation is varied. It is an underdiagnosed pathology in Colombia.
Ángela Pedraza, María Isabel Vargas-Rumilla, Juan Leandro Ramírez-Roa   +2 more
doaj   +1 more source