Results 41 to 50 of about 18,607 (256)

Exploring Multidimensional Risk Factors Associated with Local Adverse Reactions to Subcutaneous Immunoglobulin Therapy: Insights from a Nationwide Multicenter Study

Biomedicines
Background/Objectives: Subcutaneous immunoglobulin (SCIg) is a well-established alternative to intravenous immunoglobulin (IVIg) in patients with primary (PID) and secondary immunodeficiency (SID), with demonstrated benefits in safety and quality of life.
Sandra Martínez Mercader, Victor Garcia-Bustos, Pedro Moral Moral, Carmen Martínez Buenaventura, Elisa Escudero Vergara, María Carmen Montaner Bosch, Héctor Balastegui-Martín, Sonia Galindo Maycas, Miriam González Amores, Noemí Gimenez Sanz, Marian Escobar Palazón, María Moreno Mulet, Ignacio Campanero Carrasco, Alicia López, Carlos Daniel Hernández Ruiz, Laura Ruiz-López, Rocío Guzmán Guzmán, Marta Dafne Cabañero-Navalon   +17 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human inmmunoglobulin in primary immunodeficiencies

Acta Pediátrica de México, 2014
Human immunoglobulin replacement therapy has become a corner- stone in the treatment of patients with primary immunodeficiencies (PID). Currently indicated as first-line therapy for predominantly antibody deficiencies, severe combined immunodeficiencies,
Sheffler Mendoza Selma, Partida Gaytán Armando, Yamazaki Nakashimada Marco Antonio   +2 more
doaj   +1 more source

Neutropenia in primary immunodeficiency [PDF]

Current Opinion in Hematology, 2013
Neutropenia is a feature of several primary immunodeficiency diseases (PIDDs). Because of the diverse pathophysiologies of the PIDDs and the rarity of each disorder, data are often lacking, leading to the necessity of empiric treatment. Recent developments in the understanding of neutropenia in several of the PIDDs make a review of the data timely.The ...
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic basis of primary immunodeficiencies. Combined immunodeficiencies (review)

Каразінський імунологічний журнал
Background. Primary immunodeficiencies are a large and heterogeneous group of hereditary disorders characterized by disorders in the development, functioning or regulation of the immune system.
L.V. Bieliaieva, K.V. Vovk, L.L. Sherstiuk, O.O. Vlasenko   +3 more
doaj   +1 more source

First Universal Newborn Screening Program for Severe Combined Immunodeficiency in Europe. Two-Years' Experience in Catalonia (Spain)

Frontiers in Immunology, 2019
Severe combined immunodeficiency (SCID), the most severe form of T-cell immunodeficiency, can be screened at birth by quantifying T-cell receptor excision circles (TRECs) in dried blood spot (DBS) samples.
Ana Argudo-Ramírez, Andrea Martín-Nalda, Jose L. Marín-Soria, Rosa M. López-Galera, Sonia Pajares-García, Jose M. González de Aledo-Castillo, Mónica Martínez-Gallo, Marina García-Prat, Roger Colobran, Roger Colobran, Jacques G. Riviere, Yania Quintero, Tatiana Collado, Judit García-Villoria, Antonia Ribes, Pere Soler-Palacín   +15 more
doaj   +1 more source

Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases?

Frontiers in Immunology, 2021
Autoimmune diseases recognize a multifactorial pathogenesis, although the exact mechanism responsible for their onset remains to be fully elucidated.
Elena Gianchecchi, Elena Gianchecchi, Domenico V. Delfino, Alessandra Fierabracci   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

Frontiers in Immunology, 2014
We report the updated classification of primary immunodeficiencies compiled by the Expert Committee of the International Union of Immunological Societies.
Waleed eAl-Herz, Waleed eAl-Herz, Aziz eBousfiha, Jean-Laurent eCasanova, Jean-Laurent eCasanova, Talal eChatila, Talal eChatila, Mary Ellen eConley, Charlotte eCunningham-Rundles, Amos eEtzioni, Jose Luis Franco, Hubert Bobby Gaspar, Steven eHolland, Christoph eKlein, Shigeaki eNonoyama, Hans eOchs, Eric eOksenhendler, Capucine ePicard, Capucine ePicard, Jennifer ePuck, Kathleen eSullivan, Mimi eTang, Mimi eTang   +22 more
doaj   +1 more source