Results 91 to 100 of about 4,951,275 (263)

Primary immunodeficiency and the microbiome

, 2023
Purpose of review  The current understanding of the relationship of the microbiota to clinical manifestation in patients with primary immunodeficiency, specifically the inflammatory processes caused by or that result in microbial dysbiosis, and their ...
Al-Nesf Maryam Ali (16322808), Mohamed-Ali Vidya (16322821), Morgan David (344233)   +2 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome

Nature Communications
Primary antiphospholipid syndrome (PAPS) is a life-threatening clotting disorder mediated by pathogenic autoantibodies. Here we dissect the origin of self-reactive B cells in human PAPS using peripheral blood and bone marrow of patients with triple ...
Yannick Dieudonné, Raquel Lorenzetti, Julien Rottura, Iga Janowska, Quentin Frenger, Léa Jacquel, Olivier Vollmer, Francesco Carbone, Zhu Chengsong, Marine Luka, Sabine Depauw, Nadège Wadier, Stéphane Giorgiutti, Benoît Nespola, Agathe Herb, Reinhard Edmund Voll, Aurélien Guffroy, Vincent Poindron, Mickaël Ménager, Thierry Martin, Pauline Soulas-Sprauel, Marta Rizzi, Anne-Sophie Korganow, Vincent Gies   +23 more
doaj   +1 more source

Immune defects in active mycobacterial diseases in patients with primary immunodeficiency diseases (PIDs)

Journal of the Formosan Medical Association, 2011
Natural human immunity to the mycobacteria group, including Mycobacterium tuberculosis, Bacille Calmette-Guérin (BCG) or nontuberculous mycobacteria (NTM), and/or Salmonella species, relies on the functional IL-12/23-IFN-γ integrity of macrophages ...
Wen-I Lee, Jing-Long Huang, Kuo-Wei Yeh, Tang-Her Jaing, Tzou-Yien Lin, Yhu-Chering Huang, Cheng-Hsun Chiu   +6 more
doaj   +1 more source

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

, 2021
Background. Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition ...
Akyol D., Akyol Deniz, Ardeniz Fatma Omur, Ismayilov R., Ismayilov Rashad, Simsir I.Y., Ardeniz F.O., Simsir Ilgin Yildirim, Akyol, Deniz, Simsir, Ilgin Yildirim, Ismayilov, Rashad, Ardeniz, Fatma Omur, Rashad Ismayilov, Ilgin Yildirim Simsir, Fatma Omur Ardeniz, Deniz Akyol   +15 more
core   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Subjective assessment of sleep quality in adult patients with hereditary angioedema

Frontiers in Neurology
BackgroundHereditary angioedema (HAE) is a rare disorder characterized by recurrent swelling episodes, including painful abdominal attacks and life-threatening angioedema of the larynx that significantly affects patients’ quality of life, including sleep.
Esra Karabiber, Ezgi Yalçın Güngören, Ezgi Yalçın Güngören, Ezgi Yalçın Güngören, Ahmet Özen, Ahmet Özen, Ahmet Özen, Safa Barış, Safa Barış, Safa Barış, Elif Karakoc-Aydiner, Elif Karakoc-Aydiner, Elif Karakoc-Aydiner   +12 more
doaj   +1 more source

Causes, types and detection of primary immunodeficiency

, 2022
V delu je predstavljen pojem imunska pomanjkljivost. Ker gre za širok spekter bolezenskih stanj, je v delu podrobneje opisan sklop primarnih imunskih pomanjkljivosti. Te namreč med seboj zaradi lažje preglednosti ločimo v devet podkategorij.
Hočevar, Domen
core  

Cutaneous manifestations of genodermatoses and primary immunodeficiency [PDF]

, 2019
Immunodeficiency is most commonly related to inherited syndromes, infections, chemotherapy, or aging. As the population of individuals with immunodeficiency continues to grow, physicians are confronted with the task of diagnosing dermatologic disease in ...
Wu, Julie H, Boyd, McKenna, Lewis, Daniel J, Feldman, Steven R, Duvic, Madeleine, Julie H Wu, Steven R Feldman, Daniel J Lewis, Lewis, Daniel J ; Wu, Julie H ; Boyd, McKenna ; Duvic, Madeleine ; Feldman, Steven R, Madeleine Duvic, McKenna Boyd   +10 more
core   +1 more source