Results 71 to 80 of about 4,951,275 (263)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Severe gastrointestinal cytomegalovirus infection in a patient diagnosed with late onset combined immunodeficiency

European Journal of Case Reports in Internal Medicine
Late onset combined immunodeficiency (LOCID) is a rare variant of common variable immunodeficiency (CVID), typically affecting adult patients who present with opportunistic infections (OI) and/or low CD4+ T lymphocytes.
Georgina Sauqué Pintos, Arnau Antolí Gil, Gemma Rocamora Blanch, Renzo Avila Espinoza, Rosario Taco Sánchez, Núria Sabé Fernández, Xavier Solanich Moreno   +6 more
doaj   +1 more source

Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity [PDF]

, 2020
BACKGROUND: Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and ...
Pashangzadeh, S., Mahdaviani, S. A., Sherkat, Roya, Ashournia, P., Tafakoridelbari, M., Mohsenzadeh, A., Nabavi, M., Bemanian, M. H., Salami, F., Mesdaghi, M., Rasouli, S.E., Abolhassani, H., Arshi, S., Jamee, M., Rasouli, S. E., Asgardoon, M.H., Negahdari, B., Rezaei, A., Delavari, S., Hassanpour, G., Momen, T., Haji-Abadi, M. R., Chavoshzadeh, Z., Sharafian, S., Sohani, M., Khoshkhui, M., Tafaroji, J., Aghamohammadi, A., Darougar, S., Ghalebaghi, B., Behniafard, N., Ghaffari, J., Esmaeilzadeh, H., Mohammadi, J., Jabbari-Azad, F., Shariat, M., Asgardoon, M. H., Azizi, G., Momen, Tooba, Sherkat, R., Rezaei, N., Rahimi Haji-Abadi, M., Bemanian, M.H., Babaha, F., Cheraghi, T., Shakerian, Behzad, Khazaei, H. A., Shirmast, P., Mamishi, S., Razaghian, A., Khazaei, H.A., Heidarzadeh, M., Ahmadiafshar, A., Ahanchian, H., Kalantari, A., Fallahpour, M., Tavakol, M., Samavat, A., Khalili, A., Alyasin, S., Fathi, S. M., Eslamian, M.H., Sadeghi-Shabestari, M., Yazdani, R., Fathi, S.M., Ebrahimi, S., Vosughimotlagh, A., Eslamian, M. H., Kalmarzi, R. N., Shafiei, A., Molatefi, R., Nasiri Kalmarzi, R., Moghtaderi, M., Shirkani, A., Mahdaviani, S.A., Shakerian, B., Darabi, B., Dabbaghzadeh, A., Pashangzadeh, S, Kalantari, A, Jamee, M, Shafiei, A, Yazdani, R, Asgardoon, MH, Shariat, M, Salami, F, Azizi, G, Sohani, M   +87 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Other well-defined immunodeficiency syndromes

, 2012
Five broad and major groups of PID classification have been known as CID, PAD, phagocyte disorders, complement deficiencies, as well as other well-defined immunodeficiency syndromes. The former includes Wiskott-Aldrich syndrome (WAS), which presents as a

core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Primary immunodeficiency disorders in children with Non-Cystic Fibrosis Bronchiectasis.

, 2020
Introduction. Primary immunodeficiency diseases (PID) are common in patients with non-cystic fibrosis bronchiectasis (NCFB).
Tezcan, Y, Dogru, D, Pehlivanturk, Kyzylkan, Kiper, N, Yalcyn, E, Cagdas, DENİZ NAZİRE, Emiralioglu, NAGEHAN, Tagiyev, A, Keleþ, A, OzCelik, U   +9 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source