Results 131 to 140 of about 4,951,275 (263)

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

An Overview of Immunodeficiency Disorders

, 2019
This chapter provides a brief overview of major primary and acquired immunodeficiency disorders of the human immune system. It aims to assimilate information regarding immunodeficiency diseases, their current classification, causes and treatment options.
Ranjini Valiathan, Anil K. Sharma, Suresh Pallikkuth, Sudheesh Pilakka Kanthikeel, Varghese K. George, Sharma, Anil K, Kanthikeel, Sudheesh Pilakka, Pallikkuth, Suresh, George, Varghese K, Valiathan, Ranjini   +9 more
core   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene

, 2016
Background We investigated 7 male patients (from 5 different families) presenting with profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and neutropenia, a poor immune response to vaccine antigens, and increased susceptibility to ...
Dalm, Virgil A S H V.A., Durand, Amandine, Kracker, S, Pic, Isabelle, Dalm, Virgil A., Gijn, Marielle, Van, Gandemer, V, Gijn, Marielle,, Durandy, Anne, van Gijn, M, Cosset, François-Loïc, Magerus-Chatinet, A, Gandemer, Virginie, Mahlaoui, N, Hivroz, C, Cavazzana-Calvo, Marina, Fischer, Alain, de Saint Basile, Geneviève, Ouchani, Farid, Luce, S, Rieux-Laucat, F, Dalm, Virgil A, Saint Basile, Geneviève,, Soheili, T S, Hivroz, Claire, Chouteau, Myriam, Cosset, FL, Stephan, Jean Louis, Soheili, Tayebeh Shabi, Lambert, Nathalie, Majewski, J, Jabado, N, Rieux-Laucat, Frédéric, Durandy, A, Chouteau, M, Bohineust, A, Mahlaoui, Nizar, Picard, C, François-Loïc, Cosset, Saint Basile, Geneviève, De, Brouzes, C, Cavazzana, Marina, Brouzes, Chantal, van Gijn, Marielle, Magerus-Chatinet, Aude, Verhoeyen, Els, Sadek, Hanem, Andre-Schmutz, I, Pic, I, Heijmans, Catherine, Verhoeyen, E, Cavazzana, M, Stephan, Jean-Louis, Fischer, A, Van Gijn, Mariëlle M.E., Majewski, Jacek, Sadek, H, de Saint Basile, G, Luce, Sonia, Monnier, D, Durand, A, Monnier, Delphine, Kracker, Sven, André-Schmutz, Isabelle, Lambert, N, Ouchani, F, Picard, Isabelle, Heijmans, C, Stephan, J L, Dalm, V.A.S.H., Jabado, Nada, Lagresle-Peyrou, Chantal, Bohineust, Armelle, Picard, Capucine, Lagresle-Peyrou, C, Genetica Sectie Genoomdiagnostiek, Infection & Immunity   +76 more
core   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Autoimmunity in human primary immunodeficiency diseases

, 2002
Human primary immunodeficiency diseases are experiments of nature characterized by an increased susceptibility to infection. In many cases, they are also associated with troublesome and sometimes life-threatening autoimmune complications. In the past few
Cant, Andrew J., Abinun, Mario, Peter D. Arkwright, Arkwright, Peter D.; id_orcid, Andrew J. Cant, Mario Abinun   +5 more
core   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source