Results 171 to 180 of about 728,235 (280)

Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry.

Anal Biochem, 2023
Farke N, Schramm T, Verhülsdonk A, Rapp J, Link H.   +4 more
europepmc   +1 more source

In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes. [PDF]

ACS Pharmacol Transl Sci, 2022
Batool S, Furqan T, Hasan Mahmood MS, Tweedie D, Kamal MA, Greig NH.   +5 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice. [PDF]

Front Pharmacol, 2021
Zhao J, Zhou T, Lu JZ, Ye D, Mu S, Tian XH, Zhang WD, Ma BL.   +7 more
europepmc   +1 more source

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

Profiles of Essential Oils and Correlations with Phenolic Acids and Primary Metabolites in Flower Buds of Magnolia heptapeta and Magnolia denudata var. purpurascens. [PDF]

Molecules, 2021
Hyeon H, Hyun HB, Go B, Kim SC, Jung YH, Ham YM.   +5 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Quantification of "Cold-Hot" Medicinal Properties of Chinese Medicines Based on Primary Metabolites and Fisher's Analysis.

Comput Math Methods Med, 2022
Wang XR, Cao TT, Tian XM, Wang H, Wang Y.   +4 more
europepmc   +1 more source

Untargeted Metabolomics Reveals Alterations in the Primary Metabolites and Potential Pathways in the Vegetative Growth of Morchella sextelata. [PDF]

Front Mol Biosci, 2021
Deng K, Lan X, Fang Q, Li M, Xie G, Xie L.   +5 more
europepmc   +1 more source

PRIMARY METABOLITES, SECONDARY METABOLITES AND ANTIOXIDANT ACTIVITIES OF Hydrocotyle bonariensis AND Centella asiatica

Fundamental and Applied Agriculture, 2021
Zainol Haida, Mahmood Maziah, Mansor Hakiman   +2 more
openaire   +1 more source