Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
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Molecular regulation of functions of <i>Pseudomonas protegens</i> by primary metabolites in the rhizosphere: Systematic analyses and applications to agriculture. [PDF]
Plant Biotechnol (Tokyo)Takeuchi K, Seo S.
europepmc +1 more source
Profiling of Primary Metabolites and Volatiles in Apricot (Prunus armeniaca L.) Seed Kernels and Fruits in the Context of Its Different Cultivars and Soil Type as Analyzed Using Chemometric Tools. [PDF]
Foods, 2022 Farag MA +4 more
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Cyclosporine and its metabolites in mother and baby [PDF]
, 1988 Burckart, GJ +5 more
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Advanced Science, EarlyView.xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben +4 more
wiley +1 more source
Genome-wide association analysis and linkage mapping decipher the genetic control of primary metabolites and quality traits in Capsicum. [PDF]
Plant Jvon Steimker J +6 more
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Investigating metabolite channelling in primary plant metabolism
, 2016 The tricarboxylic acid (TCA) cycle is one of the central pathways in respiration and also plays an important role in a variety of metabolic processes including the synthesis of secondary metabolites and the provision of carbon skeletons for ammonium assimilation and amino acid biosynthesis.
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Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
PRIMARY METABOLITES POTERIUM POLYGAMUM WALDST. ET KIT.
Chemistry of plant raw materialThe plant Poterium polygamum, or also another scientific name Balearic burnet (Sanguisorba minor), is considered a valuable raw material for the medical and cosmetic industries. This article provides a comparative and quantitative analysis of water-soluble vitamins and amino acids using the gradient elution mode based on the high-performance liquid ...
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