Results 51 to 60 of about 379,044 (301)

Motor cortex and gait in mild cognitive impairment: a magnetic resonance spectroscopy and volumetric imaging study [PDF]

, 2013
Gait disorders are common in the course of dementia, even at the stage of mild cognitive impairment, owing to probable changes in higher levels of motor control. Since motor control message is ultimately supported in the brain by the primary motor cortex
C. Annweiler, J.L. Wells, M. Montero-Odasso, M.J. Borrie, O. Beauchet, R. Bartha, V. Hachinski   +6 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Context-dependent limb movement encoding in neuronal populations of motor cortex

Nature Communications, 2019
Network activity in primary motor cortex (M1) controls dexterous limb movements. Here, the authors show that the M1 population code varies according to contextual motor demands that are conveyed via the secondary motor cortex (M2).
Wolfgang Omlor, Anna-Sophia Wahl, Pia Sipilä, Henry Lütcke, Balazs Laurenczy, I-Wen Chen, Lazar T. Sumanovski, Marcel van ’t Hoff, Philipp Bethge, Fabian F. Voigt, Martin E. Schwab, Fritjof Helmchen   +11 more
doaj   +1 more source

Concurrent TMS to the primary motor cortex augments slow motor learning [PDF]

NeuroImage, 2014
Transcranial magnetic stimulation (TMS) has shown promise as a treatment tool, with one FDA approved use. While TMS alone is able to up- (or down-) regulate a targeted neural system, we argue that TMS applied as an adjuvant is more effective for repetitive physical, behavioral and cognitive therapies, that is, therapies which are designed to alter the ...
Shalini, Narayana, Wei, Zhang, William, Rogers, Casey, Strickland, Crystal, Franklin, Jack L, Lancaster, Peter T, Fox   +6 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Spatio-Temporal Patterning in Primary Motor Cortex at Movement Onset [PDF]

, 2017
Voluntary movement initiation involves the engagement of large populations of motor cortical neurons around movement onset. Despite knowledge of the temporal dynamics that lead to movement, the spatial structure of these dynamics across the cortical ...
Best, Matthew D., Brown, Kevin A., Hatsopoulos, Nicholas G., Suminski, Aaron J., Takahashi, Kazutaka   +4 more
core   +1 more source

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke. [PDF]

, 2018
Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks.
A Berényi, A Delorme, AK Bansal, AM Taplin, April K. Hishinuma, B Fritsch, B Lafon, B Rosin, BR Cowley, C Allman, CC Wong, CE Brown, D Ramanathan, D Reato, DC Rogers, DH Lim, Dhakshin S. Ramanathan, DJ Guggenmos, DS Ramanathan, E Aarts, Edward F. Chang, EF Chang, EJ Plautz, EJ Plautz, EZ Longa, G Stefanics, G Wallstrom, Gray Davidson, IQ Whishaw, J Godlove, J Kitamura, J Rickert, JG O’Leary, JP Donoghue, K Ganguly, K Sasaki, Karunesh Ganguly, Ling Guo, M Bikson, M Corbetta, M Honda, M Mollazadeh, M Nishibe, MA Dimyan, MA Nitsche, MH Friedberg, MM Ali, MM Churchland, MM Churchland, N Birbaumer, OA Gharbawie, R Levy, Raymond A. Swanson, RC Dossi, RD Flint, RD Flint, RD Flint, RJ Nudo, RM Levy, Robert T. Knight, S Hashimoto, S Makeig, Seok-Joon Won, ST Carmichael, T Gulati, T Gulati, Tanuj Gulati, TM Hall, TM Hall, WE DeCoteau, WJ Kargo   +70 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Dual-hemispheric transcranial direct current stimulation (tDCS) over primary motor cortex does not affect movement selection.

PLoS ONE, 2019
Volition and sense of agency are two primary components of a voluntary or internally generated movement. It has been shown that movement selection cannot be altered without interfering with the sense of volition using single pulse transcranial magnetic ...
Nivethida Thirugnanasambandam, Felix G Contreras-Castro, Mark Hallett   +2 more
doaj   +1 more source

Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge. [PDF]

, 2019
The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation.
Baker, Dewleen G, Davis, Bryan, Huang, Charles, Huang, Mingxiong, Kimball, Donald, Lerman, Imanuel, Proudfoot, James, Rao, Ramesh, Simmons, Alan N, Simon, Bruce, Sorkin, Linda, Spadoni, Andrea, Strigo, Irina, Zhong, Edward   +13 more
core   +2 more sources