Results 71 to 80 of about 214,996 (309)

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Unmasking of latent synaptic connections in the cortex of the rat, elicited by a facial nerve transection [PDF]

, 2001
Peripheral nerve injury elicits plastic changes in the cortex, resulting in reorganization of the somatotopic representation maps. These processes begin within minutes after nerve injury, and last for weeks.
Toldi, József, Toldi József, Farkas, Tamás, Farkas Tamás   +3 more
core  

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration.

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
core   +1 more source

Direction of Movement Is Encoded in the Human Primary Motor Cortex [PDF]

PLoS ONE, 2011
The present study investigated how direction of hand movement, which is a well-described parameter in cerebral organization of motor control, is incorporated in the somatotopic representation of the manual effector system in the human primary motor cortex (M1).
Toxopeus, Carolien M., de Jong, Bauke M., Valsan, Gopal, Conway, Bernard A., Leenders, Klaus L., Maurits, Natasha M.   +5 more
openaire   +7 more sources

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down

The Journal of Headache and Pain, 2020
Background Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear.
Jaisan Islam, Elina KC, Byeong Ho Oh, Soochong Kim, Sang-hwan Hyun, Young Seok Park   +5 more
doaj   +1 more source

Contribution of the primary motor cortex to motor imagery: A subthreshold TMS study [PDF]

Human Brain Mapping, 2010
AbstractMotor imagery (MI) mostly activates the same brain regions as movement execution (ME) including the primary motor cortex (Brodmann area 4, BA4). However, whether BA4 is functionally relevant for MI remains controversial. The finding that MI tasks are impaired by BA4 virtual lesions induced by transcranial magnetic stimulation (TMS) supports ...
Pelgrims, Barbara, Michaux, Nicolas, Olivier, Etienne, Andres, Michael   +3 more
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Different brain circuits underlie motor and perceptual representations of temporal intervals [PDF]

, 2008
In everyday life, temporal information is used for both perception and action, but whether these two functions reflect the operation of similar or different neural circuits is unclear.
Walsh, V., Bueti, D., Rees, G., Chris Frith, Frith, C, Bueti, Domenica, Walsh, V, Vincent Walsh, Geraint Rees, Frith, C., Domenica Bueti   +10 more
core   +1 more source