Results 71 to 80 of about 5,960,714 (302)

fNIRS Study of Brain Activation during Multiple Motor Control Conditions in Younger and Older Adults

Journal of Integrative Neuroscience
Background: Evidence suggests that aging contributes to decreased cerebral blood flow and brain oxyhemoglobin (HbO2) in the association cortices during rest.
Duoduo Yu, Conghui Wei, Zhen Yuan, Jun Luo   +3 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Dual-hemispheric transcranial direct current stimulation (tDCS) over primary motor cortex does not affect movement selection.

PLoS ONE, 2019
Volition and sense of agency are two primary components of a voluntary or internally generated movement. It has been shown that movement selection cannot be altered without interfering with the sense of volition using single pulse transcranial magnetic ...
Nivethida Thirugnanasambandam, Felix G Contreras-Castro, Mark Hallett   +2 more
doaj   +1 more source

A blueprint for movement: functional and anatomical representations in the human motor system [PDF]

, 1999
Despite a clear somatotopic organization of the motor cortex, a movement can be learned with one extremity and performed with another. This suggests that there exists a limbindependent coding for movements. To dissociate brain regions coding for movement
Buchel, C, Rijntjes, M., Dettmers, C., Kiebel, S, Frackowiak, RSJ, Weiller, C, Rijntjes, M, Dettmers, C, Frackowiak, R., Kiebel, S., Weiller, C.   +10 more
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Fine-grained nociceptive maps in primary somatosensory cortex [PDF]

, 2012
Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
Longo, Matthew R., Iannetti, GD, Sereno, MI, Iannetti, G.D., Longo, MR, Haggard, P, ,, Mancini, F, Mancini, F., Haggard, P., Sereno, Martin I.   +10 more
core   +1 more source

Direction of Movement Is Encoded in the Human Primary Motor Cortex [PDF]

PLoS ONE, 2011
The present study investigated how direction of hand movement, which is a well-described parameter in cerebral organization of motor control, is incorporated in the somatotopic representation of the manual effector system in the human primary motor cortex (M1).
Toxopeus, Carolien M., de Jong, Bauke M., Valsan, Gopal, Conway, Bernard A., Leenders, Klaus L., Maurits, Natasha M.   +5 more
openaire   +7 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Effect of electroacupuncture stimulation of “Sibai”（ST2） and “Quanliao”（SI18） on excitatory neurons of sensorimotor cortex in mice

针刺研究
ObjectiveTo observe the activation state and neuronal types of somatosensory cortex and the primary motor cortex induced by electroacupuncture （EA） stimulation of “Sibai” （ST2） and “Quanliao” （SI18） acupoints in mice.MethodsMale C57BL/6J mice were ...
ZHANG Zhi-qing, SHEN Chen-wei, CHEN Ming-quan, DU Zi-fei, CHEN Qiu-yi, JI Chang, ZHANG Wen-jie, XU Neng-gui, LIU Jian-hua   +8 more
doaj   +2 more sources

Betz cells of the primary motor cortex

Journal of Comparative Neurology
Abstract Betz cells, named in honor of Volodymyr Betz (1834–1894), who described them as “giant pyramids” in the primary motor cortex of primates and other mammalian species, are layer V extratelencephalic projection (ETP) neurons that directly innervate α‐motoneurons of the brainstem and spinal cord.
Matthew Nolan, Connor Scott, Patrick. R. Hof, Olaf Ansorge   +3 more
openaire   +2 more sources