Results 51 to 60 of about 381,907 (300)

Body Topography Parcellates Human Sensory and Motor Cortex [PDF]

, 2017
The cytoarchitectonic map as proposed by Brodmann currently dominates models of human sensorimotor cortical structure, function, and plasticity. According to this model, primary motor cortex, area 4, and primary somatosensory cortex, area 3b, are ...
Bazin, P-L, Dinse, J, Jakobsen, E, Kuehn, E, Long, X, Margulies, DS, Schäfer, A, Sereno, MI, Villringer, A   +8 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcranial magnetic stimulation as a new tool to control pain perception. [PDF]

, 2015
Treatment for chronic pain is frequently unsuccessful or characterized by side-effects. The high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has been suggested in the management of refractory chronic pain.
Frasca, Vittorio, Gori, MARIA CRISTINA, Inghilleri, Maurizio, Onesti, Emanuela   +3 more
core   +1 more source

Involvement of Primary Motor Cortex in Motor Imagery: A Neuromagnetic Study

NeuroImage, 1997
Functional brain imaging studies have indicated that several cortical and subcortical areas active during actual motor performance are also active during imagination or mental rehearsal of movements. Recent evidence shows that the primary motor cortex may also be involved in motor imagery.
A, Schnitzler, S, Salenius, R, Salmelin, V, Jousmäki, R, Hari   +4 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Context-dependent limb movement encoding in neuronal populations of motor cortex

Nature Communications, 2019
Network activity in primary motor cortex (M1) controls dexterous limb movements. Here, the authors show that the M1 population code varies according to contextual motor demands that are conveyed via the secondary motor cortex (M2).
Wolfgang Omlor, Anna-Sophia Wahl, Pia Sipilä, Henry Lütcke, Balazs Laurenczy, I-Wen Chen, Lazar T. Sumanovski, Marcel van ’t Hoff, Philipp Bethge, Fabian F. Voigt, Martin E. Schwab, Fritjof Helmchen   +11 more
doaj   +1 more source

Lmo4 Establishes Rostral Motor Cortex Projection Neuron Subtype Diversity [PDF]

, 2013
The mammalian neocortex is parcellated into anatomically and functionally distinct areas. The establishment of area-specific neuronal diversity and circuit connectivity enables distinct neocortical regions to control diverse and specialized functional ...
Azim, E., Cederquist, G. Y., Macklis, Jeffrey Daniel, Padmanabhan, Hari, Shnider, S. J.   +4 more
core   +1 more source

Multisensory integration and motor resonance in the primary motor cortex

Cortex
Humans are endowed with a motor system that resonates to speech sounds, but whether concurrent visual information from lip movements can improve speech perception at a motor level through multisensory integration mechanisms remains unknown. Therefore, the aim of the study was to explore behavioral and neurophysiological correlates of multisensory ...
Serena Giurgola, Emanuele Lo Gerfo, Alessandro Farnè, Alice C. Roy, Nadia Bolognini   +4 more
openaire   +5 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Spatio-Temporal Patterning in Primary Motor Cortex at Movement Onset [PDF]

, 2017
Voluntary movement initiation involves the engagement of large populations of motor cortical neurons around movement onset. Despite knowledge of the temporal dynamics that lead to movement, the spatial structure of these dynamics across the cortical ...
Best, Matthew D., Brown, Kevin A., Hatsopoulos, Nicholas G., Suminski, Aaron J., Takahashi, Kazutaka   +4 more
core   +1 more source