Results 61 to 70 of about 381,907 (300)
Motor cortex and gait in mild cognitive impairment: a magnetic resonance spectroscopy and volumetric imaging study [PDF]
, 2013 Gait disorders are common in the course of dementia, even at the stage of mild cognitive impairment, owing to probable changes in higher levels of motor control. Since motor control message is ultimately supported in the brain by the primary motor cortex
C. Annweiler +6 more
core +3 more sources
Conversion of Sensory Signals into Motor Commands in Primary Motor Cortex [PDF]
The Journal of Neuroscience, 1998 Movement triggered by sensory stimuli requires that the networks generating the motor commands receive an adequate driving input, which, in general, is a transformed version of the initial sensory signal. We investigated the nature of this transformation in a task in which monkeys categorize the speed of tactile stimuli as either low or high, reaching ...
E, Salinas, R, Romo
openaire +2 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
PLoS ONE, 2019 Volition and sense of agency are two primary components of a voluntary or internally generated movement. It has been shown that movement selection cannot be altered without interfering with the sense of volition using single pulse transcranial magnetic ...
Nivethida Thirugnanasambandam +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
fNIRS Study of Brain Activation during Multiple Motor Control Conditions in Younger and Older Adults
Journal of Integrative NeuroscienceBackground: Evidence suggests that aging contributes to decreased cerebral blood flow and brain oxyhemoglobin (HbO2) in the association cortices during rest.
Duoduo Yu +3 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
, 2018 Analogous to the mirror neuron system repeatedly described in monkeys as a possible substrate for imitation learning and/or action understanding, a neuronal execution/observation matching system (OEMS) is assumed in humans, but little is known to what ...
Ball, Tonio +3 more
core +1 more source
Temporal Evolution of Both Premotor and Motor Cortical Tuning Properties Reflect Changes in Limb Biomechanics [PDF]
, 2015 A prevailing theory in the cortical control of limb movement posits that premotor cortex initiates a high-level motor plan that is transformed by the primary motor cortex (MI) into a low-level motor command to be executed.
Hatsopoulos, Nicholas G. +3 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source