Results 61 to 70 of about 379,044 (301)

Conversion of Sensory Signals into Motor Commands in Primary Motor Cortex [PDF]

The Journal of Neuroscience, 1998
Movement triggered by sensory stimuli requires that the networks generating the motor commands receive an adequate driving input, which, in general, is a transformed version of the initial sensory signal. We investigated the nature of this transformation in a task in which monkeys categorize the speed of tactile stimuli as either low or high, reaching ...
E, Salinas, R, Romo
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

fNIRS Study of Brain Activation during Multiple Motor Control Conditions in Younger and Older Adults

Journal of Integrative Neuroscience
Background: Evidence suggests that aging contributes to decreased cerebral blood flow and brain oxyhemoglobin (HbO2) in the association cortices during rest.
Duoduo Yu, Conghui Wei, Zhen Yuan, Jun Luo   +3 more
doaj   +1 more source

Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors

Neural Plasticity, 2020
There are two neuron-level mechanisms proposed to underlie neural plasticity: recruiting neurons nearby to support the lost function (ipsilesional plasticity) and uncovering latent pathways that can assume the function that was lost (contralesional ...
Nathan W. Kong, William R. Gibb, Suvarna Badhe, Benjamin P. Liu, Matthew C. Tate   +4 more
doaj   +1 more source

Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter [PDF]

, 2018
Stuttering is a neurodevelopmental disorder that affects the smooth flow of speech production. Stuttering onset occurs during a dynamic period of development when children first start learning to formulate sentences.
Chang, Soo-Eun, Chow, Ho Ming, Garnett, Emily O., Guenther, Frank H., Nieto-Castañón, Alfonso, Tourville, Jason A.   +5 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effects of Transcranial Direct Current Stimulation Over the Left Primary Motor Cortex on Verbal Intelligence

Frontiers in Human Neuroscience, 2022
Previous studies have shown that changes in gray matter density and volume in the left primary motor cortex are significantly associated with changes in individuals’ verbal intelligence quotient (VIQ), but not with their performance intelligence quotient
Yifan Huang, Yinling Zhang, Yizhe Zhang, Xiaoqin Mai   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Quantitative patterns of motor cortex proteinopathy across ALS genotypes

Acta Neuropathologica Communications, 2020
Degeneration of the primary motor cortex is a defining feature of amyotrophic lateral sclerosis (ALS), which is associated with the accumulation of microscopic protein aggregates in neurons and glia. However, little is known about the quantitative burden
Matthew Nolan, Connor Scott, Menuka Pallebage Gamarallage, Daniel Lunn, Kilda Carpenter, Elizabeth McDonough, Dan Meyer, Sireesha Kaanumalle, Alberto Santamaria-Pang, Martin R. Turner, Kevin Talbot, Olaf Ansorge   +11 more
doaj   +1 more source

Quantitative GABA magnetic resonance spectroscopy as a measure of motor learning function in the motor cortex after subarachnoid hemorrhage

Frontiers in Neurology, 2023
The neural mechanisms underlying gross and fine motor dysfunction after subarachnoid hemorrhage (SAH) remain unknown. The γ-aminobutyric acid (GABA) deficit hypothesis proposes that reduced neuronal GABA concentrations and the subsequent lack of GABA ...
Kenji Sugita, Mitsuhiro Anan, Hiroyuki Matsuta, Tsuyoshi Shimomura, Hirotaka Fudaba, Nobuhiro Hata, Minoru Fujiki   +6 more
doaj   +1 more source