Results 1 to 10 of about 97,838 (263)

Primary ovarian insufficiency: update on clinical and genetic findings [PDF]

Frontiers in Endocrinology
Primary ovarian insufficiency (POI) is a disorder of insufficient ovarian follicle function before the age of 40 years with an estimated prevalence of 3.7% worldwide.
Silvia Federici, Raffaella Rossetti, Silvia Moleri, Elisabetta V. Munari, Maria Frixou, Marco Bonomi, Marco Bonomi, Luca Persani, Luca Persani   +8 more
doaj   +3 more sources

BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Nature Communications, 2022
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction that results in infertility. Here they show that BCN1 mutation results in premature ovarian follicle activation and atresia through dysregulation of ferroptosis.
Feixia Wang, Yifeng Liu, Feida Ni, Jiani Jin, Yiqing Wu, Yun Huang, Xiaohang Ye, Xilin Shen, Yue Ying, Jianhua Chen, Ruixue Chen, Yanye Zhang, Xiao Sun, Siwen Wang, Xiao Xu, Chuan Chen, Jiansheng Guo, Dan Zhang   +17 more
doaj   +2 more sources

Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency

Frontiers in Cell and Developmental Biology, 2023
Primary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At present, there are many treatments for primary ovarian insufficiency, but due to the complexity of the pathogenesis of primary ovarian insufficiency, the ...
Zixiang Geng, Zixiang Geng, Hailing Guo, Hailing Guo, Yifei Li, Ying Liu, Yongfang Zhao, Yongfang Zhao   +7 more
doaj   +2 more sources

The role of anti-Müllerian hormone: insights into ovarian reserve, primary ovarian insufficiency, and menopause prediction. [PDF]

Endocrine
This review highlights the role of Anti-Müllerian Hormone (AMH) in ovarian insufficiency and as a predictor of menopause. AMH, produced by granulosa cells in growing follicles, is a key marker of ovarian reserve, reflecting the remaining pool of viable ...
Karaviti E, Karaviti D, Kani ER, Chatziandreou E, Paschou SA, Psaltopoulou T, Kalantaridou S, Lambrinoudaki I.   +7 more
europepmc   +2 more sources

Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency.

J Clin Endocrinol Metab
Context Autoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.
Wang V, Walsh JA, Zell J, Verrilli LE, Letourneau JM, Johnstone EB, Allen-Brady K, Welt CK.   +7 more
europepmc   +2 more sources

Identification of genetically engineered strategies to manipulate nano-platforms presenting immunotherapeutic ligands for alleviating primary ovarian insufficiency progression. [PDF]

Cell Commun Signal
Primary ovarian insufficiency (POI) is a pathological condition characterized by the early loss of functional ovarian follicles, leading to infertility and systemic consequences affecting reproductive, skeletal, cardiovascular, and neurocognitive helath.
Zhou G, Gu Y, Zhang M, Ding J, Lu G, Hua K, Shen F.   +6 more
europepmc   +2 more sources

Searching for the 'X' factor: investigating the genetics of primary ovarian insufficiency. [PDF]

J Ovarian Res
Primary ovarian insufficiency (POI) is the cessation of ovarian function before the age of 40. The causes of POI are heterogeneous, but substantial evidence exists to support a genetic basis of POI, particularly in the critical involvement of genes on ...
Knight A, Sugin S, Jurisicova A.
europepmc   +2 more sources

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency. [PDF]

Int J Mol Sci, 2023
Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the pivotal
Xu Z, Takahashi N, Harada M, Kunitomi C, Kusamoto A, Koike H, Tanaka T, Sakaguchi N, Urata Y, Wada-Hiraike O, Hirota Y, Osuga Y.   +11 more
europepmc   +2 more sources

Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency. [PDF]

Nat Genet
Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are ...
Oddsson A, Steinthorsdottir V, Oskarsson GR, Styrkarsdottir U, Moore KHS, Isberg S, Halldorsson GH, Sveinbjornsson G, Westergaard D, Nielsen HS, Fridriksdottir R, Jensson BO, Arnadottir GA, Jonsson H, Sturluson A, Snaebjarnarson AS, Andreassen OA, Walters GB, Nyegaard M, Erikstrup C, Steingrimsdottir T, Lie RT, Melsted P, Jonsdottir I, Halldorsson BV, Thorleifsson G, Saemundsdottir J, Magnusson OT, DBDS Genomic Consortium, Banasik K, Sorensen E, Masson G, Pedersen OB, Tryggvadottir L, Haavik J, Ostrowski SR, Stefansson H, Holm H, Rafnar T, Gudbjartsson DF, Sulem P, Stefansson K.   +41 more
europepmc   +2 more sources

Endocrinology of Primary Ovarian Insufficiency: Diagnostic and Therapeutic Clues

Endocrines
Background: This paper briefly reviews the most important endocrine features of primary ovarian insufficiency (POI) and shows their relevance for the diagnosis and treatment of this condition.
Jan Tesarik
doaj   +2 more sources