Results 71 to 80 of about 97,838 (263)

Novel MEIOB variants cause primary ovarian insufficiency and non-obstructive azoospermia

Frontiers in Genetics, 2022
Background: Infertility is a global health concern. MEIOB has been found to be associated with premature ovarian insufficiency (POI) and non-obstructive azoospermia (NOA), but its variants have not been reported in Chinese patients. The aim of this study
Yurong Wang, Ling Liu, Chen Tan, Guiquan Meng, Lanlan Meng, Lanlan Meng, Lanlan Meng, Lanlan Meng, Hongchuan Nie, Juan Du, Juan Du, Juan Du, Guang-Xiu Lu, Guang-Xiu Lu, Guang-Xiu Lu, Guang-Xiu Lu, Ge Lin, Ge Lin, Ge Lin, Ge Lin, Wen-Bin He, Wen-Bin He, Wen-Bin He, Wen-Bin He, Wen-Bin He, Yue-Qiu Tan, Yue-Qiu Tan, Yue-Qiu Tan, Yue-Qiu Tan, Yue-Qiu Tan   +29 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

The effect of growth hormone on ovarian function recovery in a mouse model of ovarian insufficiency

Frontiers in Endocrinology, 2023
ObjectivesTo evaluate the effects and mechanisms of action of growth hormone (GH) in the recovery of ovarian function in ovarian insufficiency induced by cyclophosphamide (CP) in a mouse model.Materials and methodsAfter inducing ovarian insufficiency by ...
Su Mi Kim, Su Mi Kim, Jung Young Yoo, Jung Young Yoo, Yeon Hee Hong, Yeon Hee Hong, Jaewang Lee, Ji Hyang Kim, Jung Ryeol Lee, Jung Ryeol Lee   +9 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Analysis of Mexican young women with primary ovarian insufficiency induced by gynaecological and haematological cancer management

Journal of Obstetrics and Gynaecology, 2023
This was a retrospective study that included 114 women younger than 40 years with induced primary ovarian insufficiency. Patients who presented vasomotor symptoms had a higher proportion (26 [63.41%] versus 58 [79.45%], OR 2.23, 95% CI 0.95–5.23, p ...
Marisol García-García, David Cantú-de-León, Rosa Salcedo-Hernández, Aarón González-Enciso, Cintia María Sepúlveda-Rivera, Julio César González Rodríguez, Salim Abraham Barquet-Muñoz   +6 more
doaj   +1 more source

Shared Genetics Between Age at Menopause, Early Menopause, POI and Other Traits

Frontiers in Genetics, 2021
Reproductive ageing leading to menopause is characterized by depletion of follicles and its regulating mechanisms are only partly understood. Early age at menopause and premature ovarian insufficiency (POI) are associated with several other traits such ...
Yvonne V. Louwers, Jenny A. Visser
doaj   +1 more source

Yu Linzhu alleviates primary ovarian insufficiency in a rat model by improving proliferation and energy metabolism of granulosa cells through hif1α/cx43 pathway

Journal of Ovarian Research
Yu Linzhu (YLZ) is a classical Chinese traditional formula, which has been used for more than 600 years to regulate menstruation to help pregnancy. However, the mechanism of modern scientific action of YLZ needs to be further studied.
Xin Ruan, P. Wang, Ma Wei, Qingqing Yang, Xiaoying Dong   +4 more
semanticscholar   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/β-Catenin Signaling

Disease Markers, 2022
Background Primary ovarian insufficiency (POI) is a female disease characterized by ovarian function loss under 40 years old. Transplantation of exosomes is an encouraging regenerative medicine method that has the potential for restoring ovarian ...
Tian Gao, Yi Cao, Min Hu, Ying-Qiang Du
semanticscholar   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source