Results 91 to 100 of about 7,915,710 (337)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.

New England Journal of Medicine, 2018
To the Editor: Because of irregularities in the randomization procedures, we wish to retract the following article: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.
R. Estruch, E. Ros, J. Salas‐Salvadó, M. Covas, D. Corella, F. Arós, E. Gómez-Gracia, V. Ruíz-Gutiérrez, M. Fiol, J. Lapetra, R. Lamuela-Raventós, L. Serra-Majem, X. Pintó, J. Basora, M. Muñoz, J. Sorlí, J. A. Martínez, M. Martínez-González   +17 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Four-year long-term follow-up of diabetes patients after implementation of the Chronic Care Model in primary care: a cross-sectional study

Swiss Medical Weekly, 2017
AIMS Implementing the Chronic Care Model (CCM) via involvement of specially trained practice nurses improves cardiovascular risk profiles and perception of care among type 2 diabetes patients in small primary care practices (PCPs) in the ...
Corinne Chmiel, Irina Giewer, Anja Frei, Thomas Rosemann   +3 more
doaj   +1 more source

Efficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials

European Heart Journal, 2018
AIMS The role of aspirin in the primary prevention setting is continuously evolving. Recent randomized trials have challenged the role of aspirin in the primary prevention setting.
Ahmed N. Mahmoud, M. Gad, Akram Y. Elgendy, I. Elgendy, A. Bavry   +4 more
semanticscholar   +1 more source

Role of Colchicine in Prevention of Contrast Induced Nephropathy in Patient Undergoing Primary Percutaneous Coronary Intervention [PDF]

, 2021
Omar Mostafa Abdelaziz Elhodhod, Mohamed Moustafa Farouk, Hazem M Khorshed Walid A, El Hammady   +3 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

E-cigarettes – their use and harmfulness. A brief summary of current scientific knowledge

Nowotwory
The consumption of e-cigarettes has rapidly increased in the last years, both worldwide and in Poland, especially among adolescents and youth. Many e-cigarette users also smoke conventional cigarettes (“dual use”). Some researchers argue that e-cigarette
Krzysztof Przewoźniak, Paweł Koczkodaj
doaj   +1 more source

212 Educational-artistic exhibitions on the skin and the main dermatoses: PEAUrigami ® for education and primary prevention of melanoma [PDF]

, 2022
C. Dechelette
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source