Results 101 to 110 of about 4,318,091 (252)

Sclerosing Cholangitis in Baboons (Papio spp) Resembling Primary Sclerosing Cholangitis of Humans

, 2011
Primary sclerosing cholangitis is a chronic and progressive cholestatic liver disease that has been extensively documented in the human literature.
E. J. Dick Jr, A. M. Arenas-Gamboa, J. J. Bearss, M. A. Owston, B. F. Porter, G. B. Hubbard   +5 more
core   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Ketamine-Induced Sclerosing Cholangitis Associated With Early Inflammatory Bowel Disease During Chronic Topical Ketamine Use

Gastro Hep Advances
Ketamine-induced sclerosing cholangitis has been described with chronic intranasal and intravenous use. Our case follows chronic topical use for peripheral neuropathy.
Gerond Lake-Bakaar, Benjamin Milgrom, Clark Kulig, Andrea K. Sotelo, Joselle Speirs, Alexandra Meihofer   +5 more
doaj   +1 more source

IgG4-associated sclerosing cholangitis: a diagnosis that may change the course of events (review of the literature and a clinical case)

Alʹmanah Kliničeskoj Mediciny, 2018
Immunoglobulin G4-associated sclerosing cholangitis (IgG4-SC) can mimic primary sclerosing cholangitis, cholangiocarcinoma, and pancreatic adenocarcinoma. Its proper diagnosis allows for an adequate therapy and an improvement of the outcomes. The article
E. V. Vinnitskaya, T. Yu. Khaimenova, E. S. Sbikina, R. I. Alexandrova, Yu. G. Sandler   +4 more
doaj   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man

Autopsy and Case Reports, 2013
Primary sclerosing cholangitis, a chronic progressive cholestatic liver disease, is the most serious hepatobiliary complication of ulcerative colitis (UC).
José Cândido Caldeira Xavier Júnior, Kunie Iabuki Rabello Coelho, Ligia Yukie Sassaki, Fabio da Silva Yamashiro, Kelly Cristhian Lima Oliveira, Maria Aparecida Marchesan Rodrigues   +5 more
doaj  

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis [PDF]

, 2018
Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation.
Dhillon, Amandeep Kaur, Liaskou, Evaggelia, Trøseid, Marius, Moum, Bjørn, Hov, Johannes Espolin Roksund, Karlsen, Tom Hemming, Vesterhus, Mette, Åkra, Sissel, Kummen, Martin, Seljeflot, Ingebjørg   +9 more
core   +1 more source

Real‐World Cost and Utilisation Burden of Diagnosed Metabolic Dysfunction‐Associated Steatotic Liver Disease in Patients With Type 2 Diabetes in the United States: A Retrospective Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study quantified the real‐world healthcare costs and utilisation associated with diagnosed metabolic dysfunction‐associated steatotic liver disease (MASLD) among adults with Type 2 diabetes (T2D). Methods We conducted a retrospective cohort study using IQVIA PharMetrics Plus Closed Health Plan data from January 2016 to June 2025 ...
Tien Hoang Tran, Hyung‐Seok Kim, Rozalina G. McCoy, Zafar Zafari   +3 more
wiley   +1 more source

Anti‐Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric‐Onset Primary Sclerosing Cholangitis

Hepatology Research, EarlyView.
Levels of anti‐integrin αvβ6 antibodies were significantly higher in pediatric‐onset primary sclerosing cholangitis (PSC) than in autoimmune hepatitis (AIH) and may reflect disease activity. These antibodies may serve as a novel biomarker for distinguishing PSC from AIH and for monitoring disease progression.
Yukako Maeda, Shuichiro Umetsu, Eitaro Hiejima, Mitsuyoshi Suzuki, Itaru Iwama, Takeshi Kimura, Sonoko Kondo, Ayano Inui, Hiroki Kondou, Tatsuya Okamoto, Takashi Ito, Hiroyuki Shirahase, Kazushi Izawa, Takahiro Yasumi, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno, Junko Takita   +17 more
wiley   +1 more source

Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial

Trials, 2017
Background Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients with a suboptimal response to ...
Ruth Bolier, Elsemieke S. de Vries, Albert Parés, Jeltje Helder, E. Marleen Kemper, Koos Zwinderman, Ronald P. Oude Elferink, Ulrich Beuers, the Netherlands Association for the Study of the Liver (NASL) Cholestatic Liver Diseases Study Group   +8 more
doaj   +1 more source